NEDD8 (NEDD8 ubiquitin like modifier)

2003-08-01  

Identity

HGNC
LOCATION
14q12
LOCUSID
ALIAS
NEDD-8
FUSION GENES

Other Information

Locus ID:

NCBI: 4738
MIM: 603171
HGNC: 7732
Ensembl: ENSG00000129559

Variants:

dbSNP: 4738
ClinVar: 4738
TCGA: ENSG00000129559
COSMIC: NEDD8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000129559ENST00000250495Q15843
ENSG00000129559ENST00000396828F8VSA6
ENSG00000129559ENST00000524927F8VSA6

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Signal TransductionREACTOMER-HSA-162582
Signaling by TGF-beta Receptor ComplexREACTOMER-HSA-170834
TGF-beta receptor signaling activates SMADsREACTOMER-HSA-2173789
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Clathrin-mediated endocytosisREACTOMER-HSA-8856828
Cargo recognition for clathrin-mediated endocytosisREACTOMER-HSA-8856825
DeubiquitinationREACTOMER-HSA-5688426
UCH proteinasesREACTOMER-HSA-5689603

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
188050922008Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation.325
188518302008Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation.192
125040252002NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases.126
146905972003The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1.89
126469242003Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8.75
156943362005Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1.75
249499762014Structure of a RING E3 trapped in action reveals ligation mechanism for the ubiquitin-like protein NEDD8.70
206889842010Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family.69
213996172011Polyubiquitin binding and cross-reactivity in the USP domain deubiquitinase USP21.68
182745522008Ribosomal proteins are targets for the NEDD8 pathway.67

Citation

Dessen P

NEDD8 (NEDD8 ubiquitin like modifier)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41518/nedd8-(nedd8-ubiquitin-like-modifier)