NEIL2 (nei like DNA glycosylase 2)

2003-12-01  

Identity

HGNC
NEIL2
LOCATION
8p23.1
LOCUSID
252969
ALIAS
NEH2,NEI2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 252969
MIM: 608933
HGNC: 18956
Ensembl: ENSG00000154328

Variants:

dbSNP: 252969
ClinVar: 252969
TCGA: ENSG00000154328
COSMIC: NEIL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000154328ENST00000284503Q969S2
ENSG00000154328ENST00000284503A0A024R361
ENSG00000154328ENST00000403422Q969S2
ENSG00000154328ENST00000436750Q969S2
ENSG00000154328ENST00000436750A0A024R361
ENSG00000154328ENST00000455213Q969S2
ENSG00000154328ENST00000455213A0A024R361
ENSG00000154328ENST00000528113E9PPL4
ENSG00000154328ENST00000528323Q969S2

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Base excision repairKEGGko03410
Base excision repairKEGGhsa03410
DNA RepairREACTOMER-HSA-73894
Base Excision RepairREACTOMER-HSA-73884
Base-Excision Repair, AP Site FormationREACTOMER-HSA-73929
DepyrimidinationREACTOMER-HSA-73928
Recognition and association of DNA glycosylase with site containing an affected pyrimidineREACTOMER-HSA-110328
Cleavage of the damaged pyrimidineREACTOMER-HSA-110329
Resolution of Abasic Sites (AP sites)REACTOMER-HSA-73933
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement PathwayREACTOMER-HSA-5649702

References

Pubmed IDYearTitleCitations
373103992024Functional roles and cancer variants of the bifunctional glycosylase NEIL2.1
373103992024Functional roles and cancer variants of the bifunctional glycosylase NEIL2.1
379713112023Structural and biochemical insights into NEIL2's preference for abasic sites.1
380713702023The DNA glycosylase NEIL2 is protective during SARS-CoV-2 infection.1
379713112023Structural and biochemical insights into NEIL2's preference for abasic sites.1
380713702023The DNA glycosylase NEIL2 is protective during SARS-CoV-2 infection.1
347042362022Mendelian Randomization Analysis Identified Potential Genes Pleiotropically Associated with Polycystic Ovary Syndrome.4
347570572022Dynamics and Conformational Changes in Human NEIL2 DNA Glycosylase Analyzed by Hydrogen/Deuterium Exchange Mass Spectrometry.5
352163292022A Low-Activity Polymorphic Variant of Human NEIL2 DNA Glycosylase.5
347042362022Mendelian Randomization Analysis Identified Potential Genes Pleiotropically Associated with Polycystic Ovary Syndrome.4
347570572022Dynamics and Conformational Changes in Human NEIL2 DNA Glycosylase Analyzed by Hydrogen/Deuterium Exchange Mass Spectrometry.5
352163292022A Low-Activity Polymorphic Variant of Human NEIL2 DNA Glycosylase.5
328461442021Unique Structural Features of Mammalian NEIL2 DNA Glycosylase Prime Its Activity for Diverse DNA Substrates and Environments.16
339252712021NEIL1 and NEIL2 Are Recruited as Potential Backup for OGG1 upon OGG1 Depletion or Inhibition by TH5487.6
340970652021Genetic variations in 3'UTRs of SMUG1 and NEIL2 genes modulate breast cancer risk, survival and therapy response.2

Citation

Dessen P

NEIL2 (nei like DNA glycosylase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/41520/css/lib/js/template.js