NME3 (NME/NM23 nucleoside diphosphate kinase 3)

2003-02-01  

Identity

HGNC
NME3
LOCATION
16p13.3
LOCUSID
4832
ALIAS
DR-nm23,NDPK-C,NDPKC,NM23-H3,NM23H3,c371H6.2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4832
MIM: 601817
HGNC: 7851
Ensembl: ENSG00000103024

Variants:

dbSNP: 4832
ClinVar: 4832
TCGA: ENSG00000103024
COSMIC: NME3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000103024ENST00000219302Q13232
ENSG00000103024ENST00000563498H3BPR2
ENSG00000103024ENST00000563854H3BMQ7
ENSG00000103024ENST00000564628H3BRA8
ENSG00000103024ENST00000568561H3BPD9

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Pyrimidine metabolismKEGGko00240
Purine metabolismKEGGhsa00230
Pyrimidine metabolismKEGGhsa00240
Metabolic pathwaysKEGGhsa01100
Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTPKEGGhsa_M00052
Adenine ribonucleotide biosynthesis, IMP => ADP,ATPKEGGM00049
Guanine ribonucleotide biosynthesis IMP => GDP,GTPKEGGM00050
Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTPKEGGM00052
Adenine ribonucleotide biosynthesis, IMP => ADP,ATPKEGGhsa_M00049
Guanine ribonucleotide biosynthesis IMP => GDP,GTPKEGGhsa_M00050

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
365227962023Genetic defects in peroxisome morphogenesis (Pex11β, dynamin-like protein 1, and nucleoside diphosphate kinase 3) affect docosahexaenoic acid-phospholipid metabolism.6
375845892023NME3 binds to phosphatidic acid and mediates PLD6-induced mitochondrial tethering.4
365227962023Genetic defects in peroxisome morphogenesis (Pex11β, dynamin-like protein 1, and nucleoside diphosphate kinase 3) affect docosahexaenoic acid-phospholipid metabolism.6
375845892023NME3 binds to phosphatidic acid and mediates PLD6-induced mitochondrial tethering.4
327089272020NME3 Regulates Mitochondria to Reduce ROS-Mediated Genome Instability.7
327089272020NME3 Regulates Mitochondria to Reduce ROS-Mediated Genome Instability.7
305875872019Two separate functions of NME3 critical for cell survival underlie a neurodegenerative disorder.21
305875872019Two separate functions of NME3 critical for cell survival underlie a neurodegenerative disorder.21
295237662018Nucleoside Diphosphate Kinase-3 (NME3) Enhances TLR5-Induced NFκB Activation.11
301115922018The nucleoside-diphosphate kinase NME3 associates with nephronophthisis proteins and is required for ciliary function during renal development.5
295237662018Nucleoside Diphosphate Kinase-3 (NME3) Enhances TLR5-Induced NFκB Activation.11
301115922018The nucleoside-diphosphate kinase NME3 associates with nephronophthisis proteins and is required for ciliary function during renal development.5
269450152016The direct interaction of NME3 with Tip60 in DNA repair.7
269450152016The direct interaction of NME3 with Tip60 in DNA repair.7
237650942013Inhibitory effect of upregulated DR-nm23 expression on invasion and metastasis in colorectal cancer.6

Citation

Dessen P

NME3 (NME/NM23 nucleoside diphosphate kinase 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41545/tumors-explorer/haematological-explorer/css/template-card.css