NOTCH4 (notch receptor 4)

2003-02-01  

Identity

HGNC
NOTCH4
LOCATION
6p21.32
LOCUSID
4855
ALIAS
INT3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4855
MIM: 164951
HGNC: 7884
Ensembl: ENSG00000204301

Variants:

dbSNP: 4855
ClinVar: 4855
TCGA: ENSG00000204301
COSMIC: NOTCH4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000204301ENST00000375023Q99466
ENSG00000204301ENST00000375023A0A1U9X983

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Dorso-ventral axis formationKEGGko04320
Notch signaling pathwayKEGGko04330
Notch signaling pathwayKEGGhsa04330
Dorso-ventral axis formationKEGGhsa04320
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
Thyroid hormone signaling pathwayKEGGhsa04919
Notch signalingKEGGhsa_M00682
Notch signalingKEGGM00682
DiseaseREACTOMER-HSA-1643685
Diseases of glycosylationREACTOMER-HSA-3781865
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Pre-NOTCH Expression and ProcessingREACTOMER-HSA-1912422
Pre-NOTCH Transcription and TranslationREACTOMER-HSA-1912408
Pre-NOTCH Processing in the Endoplasmic ReticulumREACTOMER-HSA-1912399
Pre-NOTCH Processing in GolgiREACTOMER-HSA-1912420
Signaling by NOTCH4REACTOMER-HSA-1980150
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Notch-HLH transcription pathwayREACTOMER-HSA-350054
Diseases associated with O-glycosylation of proteinsREACTOMER-HSA-3906995
Defective LFNG causes SCDO3REACTOMER-HSA-5083630
Endocrine resistanceKEGGko01522
Endocrine resistanceKEGGhsa01522
Breast cancerKEGGko05224
Breast cancerKEGGhsa05224

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA166120929severe cutaneous adverse reactionsDiseaseClinicalAnnotationassociatedPD29193002
PA448320allopurinolChemicalClinicalAnnotationassociatedPD29193002

References

Pubmed IDYearTitleCitations
388118182024Inhibition of NOTCH4 sensitizes FLT3/ITD acute myeloid leukemia cells to FLT3 tyrosine kinase inhibition.0
388118182024Inhibition of NOTCH4 sensitizes FLT3/ITD acute myeloid leukemia cells to FLT3 tyrosine kinase inhibition.0
367247522023NOTCH4 Single-Nucleotide Polymorphism Is Associated with Brain Arteriovenous Malformation in a Chinese Han Population.1
368174732023Polymorphisms and gene expression of Notch4 in pulmonary tuberculosis.0
372686352023NOTCH4(ΔL12_16) sensitizes lung adenocarcinomas to EGFR-TKIs through transcriptional down-regulation of HES1.0
374783142023NOTCH4 potentiates the IL-13 induced genetic program in M2 alternative macrophages through the AP1 and IRF4-JMJD3 axis.2
375445782023Association of NOTCH4 and ACHE gene polymorphism in Alzheimer's disease of Gujarat cohort.0
367247522023NOTCH4 Single-Nucleotide Polymorphism Is Associated with Brain Arteriovenous Malformation in a Chinese Han Population.1
368174732023Polymorphisms and gene expression of Notch4 in pulmonary tuberculosis.0
372686352023NOTCH4(ΔL12_16) sensitizes lung adenocarcinomas to EGFR-TKIs through transcriptional down-regulation of HES1.0
374783142023NOTCH4 potentiates the IL-13 induced genetic program in M2 alternative macrophages through the AP1 and IRF4-JMJD3 axis.2
375445782023Association of NOTCH4 and ACHE gene polymorphism in Alzheimer's disease of Gujarat cohort.0
355438592022Expression of NOTCH1, NOTCH4, HLA-DMA and HLA-DRA is synergistically associated with T cell exclusion, immune checkpoint blockade efficacy and recurrence risk in ER-negative breast cancer.8
359674502022NOTCH4 mutation as predictive biomarker for immunotherapy benefits in NRAS wildtype melanoma.4
360445752022JAG1-NOTCH4 mechanosensing drives atherosclerosis.6

Citation

Dessen P

NOTCH4 (notch receptor 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41558/gene-fusions/haematological-explorer/haematological-explorer