NRP1 (neuropilin 1)

2003-08-01  

Identity

HGNC
LOCATION
10p11.22
LOCUSID
ALIAS
BDCA4,CD304,NP1,NRP,VEGF165R
FUSION GENES

Other Information

Locus ID:

NCBI: 8829
MIM: 602069
HGNC: 8004
Ensembl: ENSG00000099250

Variants:

dbSNP: 8829
ClinVar: 8829
TCGA: ENSG00000099250
COSMIC: NRP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000099250ENST00000265371O14786
ENSG00000099250ENST00000374816E7EX60
ENSG00000099250ENST00000374821O14786
ENSG00000099250ENST00000374822O14786
ENSG00000099250ENST00000374823Q5T7F0
ENSG00000099250ENST00000374867O14786
ENSG00000099250ENST00000374875Q5JWQ6
ENSG00000099250ENST00000395995E9PEP6
ENSG00000099250ENST00000413802Q5JWQ2
ENSG00000099250ENST00000418675H0Y7Z2
ENSG00000099250ENST00000431894H0Y4N6
ENSG00000099250ENST00000432372Q5JWQ4
ENSG00000099250ENST00000455749H0Y4A0
ENSG00000099250ENST00000466932V9GYL7

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Signal TransductionREACTOMER-HSA-162582
Signaling by VEGFREACTOMER-HSA-194138
Neurophilin interactions with VEGF and VEGFRREACTOMER-HSA-194306
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Semaphorin interactionsREACTOMER-HSA-373755
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesionREACTOMER-HSA-399955
Sema3A PAK dependent Axon repulsionREACTOMER-HSA-399954
CRMPs in Sema3A signalingREACTOMER-HSA-399956
L1CAM interactionsREACTOMER-HSA-373760
Signal transduction by L1REACTOMER-HSA-445144
CHL1 interactionsREACTOMER-HSA-447041

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA134850558Macular DegenerationDiseaseClinicalAnnotationassociatedPD26426212
PA164746012ranibizumabChemicalClinicalAnnotationassociatedPD26426212
PA30086KDRGenePathwayassociated20124951
PA37302VEGFAGenePathwayassociated20124951
PA37303VEGFBGenePathwayassociated20124951
PA37304VEGFCGenePathwayassociated20124951

References

Pubmed IDYearTitleCitations
198052732009C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration.172
223931262012Autocrine VEGF-VEGFR2-Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth.141
285523482017Interferon-γ Drives Treg Fragility to Promote Anti-tumor Immunity.92
119537492002A neuronal receptor, neuropilin-1, is essential for the initiation of the primary immune response.91
215867482011Neuropilin-1 promotes VEGFR-2 trafficking through Rab11 vesicles thereby specifying signal output.83
234528542013Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma.80
145003502003Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells.78
175752732007Neuropilin-1 binds to VEGF121 and regulates endothelial cell migration and sprouting.78
145146742003Neuropilin-1-mediated vascular permeability factor/vascular endothelial growth factor-dependent endothelial cell migration.75
216538262011VEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration, complex formation between NRP1 and VEGFR2, and signaling via FAK Tyr407 phosphorylation.73

Citation

Dessen P

NRP1 (neuropilin 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41582/nrp1-(neuropilin-1)