OGG1 (8-oxoguanine DNA glycosylase)

2003-02-01  

Identity

HGNC
OGG1
LOCATION
3p25.3
LOCUSID
4968
ALIAS
HMMH,HOGG1,MUTM,OGH1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4968
MIM: 601982
HGNC: 8125
Ensembl: ENSG00000114026

Variants:

dbSNP: 4968
ClinVar: 4968
TCGA: ENSG00000114026
COSMIC: OGG1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000114026ENST00000302003O15527
ENSG00000114026ENST00000302003E5KPN0
ENSG00000114026ENST00000302008O15527
ENSG00000114026ENST00000302008E5KPM7
ENSG00000114026ENST00000302036O15527
ENSG00000114026ENST00000302036E5KPM5
ENSG00000114026ENST00000339511O15527
ENSG00000114026ENST00000344629O15527
ENSG00000114026ENST00000344629E5KPN1
ENSG00000114026ENST00000349503O15527
ENSG00000114026ENST00000349503E5KPM6
ENSG00000114026ENST00000352937H7BXZ1
ENSG00000114026ENST00000383826O15527
ENSG00000114026ENST00000383826E5KPM8
ENSG00000114026ENST00000416333H7C1V7
ENSG00000114026ENST00000425665F8WCZ9
ENSG00000114026ENST00000426518H7C1D7
ENSG00000114026ENST00000429146H7C0A1
ENSG00000114026ENST00000441094H7BZM3
ENSG00000114026ENST00000449570O15527
ENSG00000114026ENST00000449570E5KPM9

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Base excision repairKEGGko03410
Base excision repairKEGGhsa03410
DNA RepairREACTOMER-HSA-73894
Base Excision RepairREACTOMER-HSA-73884
Base-Excision Repair, AP Site FormationREACTOMER-HSA-73929
DepurinationREACTOMER-HSA-73927
Recognition and association of DNA glycosylase with site containing an affected purineREACTOMER-HSA-110330
Cleavage of the damaged purineREACTOMER-HSA-110331
DepyrimidinationREACTOMER-HSA-73928
Recognition and association of DNA glycosylase with site containing an affected pyrimidineREACTOMER-HSA-110328
Cleavage of the damaged pyrimidineREACTOMER-HSA-110329
Resolution of Abasic Sites (AP sites)REACTOMER-HSA-73933
Displacement of DNA glycosylase by APEX1REACTOMER-HSA-110357
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement PathwayREACTOMER-HSA-5649702

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128406956fluorouracilChemicalVariantAnnotationnot associatedPD28796378
PA164713176Platinum compoundsChemicalVariantAnnotationnot associatedPD28796378
PA166122986radiotherapyChemicalVariantAnnotationnot associatedPD28796378
PA445742Stomach NeoplasmsDiseaseVariantAnnotationnot associatedPD28796378

References

Pubmed IDYearTitleCitations
379916422024The 24-h profile of the DNA repair enzyme 8-oxoguanine glycosylase 1 (OGG1) is associated with age, TNF-α, and waist circumference in healthy adults.0
382364792024Investigation of APE1 and OGG1 expression in chronic hemodialysis patients.0
382374812024Single-molecule analysis of purified proteins and nuclear extracts: Insights from 8-oxoguanine glycosylase 1.0
383341412024Association between polymorphisms of the DNA repair genes RAD51 and OGG1 and risk of cardiovascular disease.0
383636042024OGG1 prevents atherosclerosis-induced vascular endothelial cell injury through mediating DNA damage repair.0
385541132024SIRT2 promotes base excision repair by transcriptionally activating OGG1 in an ATM/ATR-dependent manner.0
379916422024The 24-h profile of the DNA repair enzyme 8-oxoguanine glycosylase 1 (OGG1) is associated with age, TNF-α, and waist circumference in healthy adults.0
382364792024Investigation of APE1 and OGG1 expression in chronic hemodialysis patients.0
382374812024Single-molecule analysis of purified proteins and nuclear extracts: Insights from 8-oxoguanine glycosylase 1.0
383341412024Association between polymorphisms of the DNA repair genes RAD51 and OGG1 and risk of cardiovascular disease.0
383636042024OGG1 prevents atherosclerosis-induced vascular endothelial cell injury through mediating DNA damage repair.0
385541132024SIRT2 promotes base excision repair by transcriptionally activating OGG1 in an ATM/ATR-dependent manner.0
364728502023PARP1 and OGG1 in Medicated Patients With Depression and the Response to ECT.0
365280592023Nuclear factor Nrf2 promotes glycosidase OGG1 expression by activating the AKT pathway to enhance leukemia cell resistance to cytarabine.5
3698256220238-Oxoguanine DNA Glycosylase 1 Upregulation as a Risk Factor for Obesity and Colorectal Cancer.1

Citation

Dessen P

OGG1 (8-oxoguanine DNA glycosylase)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41606/css/lib/tumors-explorer/js/lib/all.min.js