PAPPA (pappalysin 1)

2003-08-01  

Identity

HGNC
LOCATION
9q33.1
LOCUSID
ALIAS
ASBABP2,DIPLA1,IGFBP-4ase,PAPA,PAPP-A,PAPPA1
FUSION GENES

Other Information

Locus ID:

NCBI: 5069
MIM: 176385
HGNC: 8602
Ensembl: ENSG00000182752

Variants:

dbSNP: 5069
ClinVar: 5069
TCGA: ENSG00000182752
COSMIC: PAPPA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000182752ENST00000328252Q13219

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)REACTOMER-HSA-381426

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
145301922003Circulating pregnancy-associated plasma protein a predicts outcome in patients with acute coronary syndrome but no troponin I elevation.34
160864432005Prediction of pregnancy complications by first-trimester maternal serum PAPP-A and free beta-hCG and with second-trimester uterine artery Doppler.32
238215252013MiR-490-3p modulates the proliferation of vascular smooth muscle cells induced by ox-LDL through targeting PAPP-A.25
123701762002Cell surface targeting of pregnancy-associated plasma protein A proteolytic activity. Reversible adhesion is mediated by two neighboring short consensus repeats.24
204727612010Transgenic overexpression of pregnancy-associated plasma protein-A in murine arterial smooth muscle accelerates atherosclerotic lesion development.22
193651672009Relationship between pregnancy-associated plasma protein-A and lung cancer.21
146570122004Pregnancy-associated plasma protein a gene expression as a target of inflammatory cytokines.18
187898002009Pregnancy-associated plasma protein-A (PAPP-A) and cardiovascular risk.18
122415452002Substrate specificity of the metalloproteinase pregnancy-associated plasma protein-A (PAPP-A) assessed by mutagenesis and analysis of synthetic peptides: substrate residues distant from the scissile bond are critical for proteolysis.17

Citation

Dessen P

PAPPA (pappalysin 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41637/pappa