PAPSS1 (3-phosphoadenosine 5-phosphosulfate synthase 1)

2003-05-01  

Identity

HGNC
PAPSS1
LOCATION
4q25
LOCUSID
9061
ALIAS
ATPSK1,PAPSS,SK1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9061
MIM: 603262
HGNC: 8603
Ensembl: ENSG00000138801

Variants:

dbSNP: 9061
ClinVar: 9061
TCGA: ENSG00000138801
COSMIC: PAPSS1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138801ENST00000265174O43252

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Selenocompound metabolismKEGGko00450
Sulfur metabolismKEGGko00920
Purine metabolismKEGGhsa00230
Selenocompound metabolismKEGGhsa00450
Sulfur metabolismKEGGhsa00920
Metabolic pathwaysKEGGhsa01100
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glycosaminoglycan metabolismREACTOMER-HSA-1630316
Transport and synthesis of PAPSREACTOMER-HSA-174362
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
Cytosolic sulfonation of small moleculesREACTOMER-HSA-156584
Selenoamino acid metabolismREACTOMER-HSA-2408522
Metabolism of ingested H2SeO4 and H2SeO3 into H2SeREACTOMER-HSA-2408550
Oncogenic MAPK signalingREACTOMER-HSA-6802957
Signaling by BRAF and RAF fusionsREACTOMER-HSA-6802952

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203352282010Role of sphingosine kinase-1 in paracrine/transcellular angiogenesis and lymphangiogenesis in vitro.46
245873392014Sphingosine kinase 1 and cancer: a systematic review and meta-analysis.36
127160562003Human 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase: biochemistry, molecular biology and genetic deficiency.23
223808442012Effect of estrogen sulfation by SULT1E1 and PAPSS on the development of estrogen-dependent cancers.22
254823032014Leptin induces upregulation of sphingosine kinase 1 in oestrogen receptor-negative breast cancer via Src family kinase-mediated, janus kinase 2-independent pathway.21
157554552005The crystal structure of human PAPS synthetase 1 reveals asymmetry in substrate binding.18
190089492008The host cell sulfonation pathway contributes to retroviral infection at a step coincident with provirus establishment.16
150658802004Human 3'-phosphoadenosine 5'-phosphosulfate synthetase (isoform 1, brain): kinetic properties of the adenosine triphosphate sulfurylase and adenosine 5'-phosphosulfate kinase domains.13
222421752012Human PAPS synthase isoforms are dynamically regulated enzymes with access to nucleus and cytoplasm.13
119316372002Characterization and expression of human bifunctional 3'-phosphoadenosine 5'-phosphosulphate synthase isoforms.11

Citation

Dessen P

PAPSS1 (3-phosphoadenosine 5-phosphosulfate synthase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41638/papss1