PBX3 (PBX homeobox 3)

2003-02-01  

Identity

HGNC
LOCATION
9q33.3
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 5090
MIM: 176312
HGNC: 8634
Ensembl: ENSG00000167081

Variants:

dbSNP: 5090
ClinVar: 5090
TCGA: ENSG00000167081
COSMIC: PBX3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167081ENST00000342287P40426
ENSG00000167081ENST00000373482H3BLX0
ENSG00000167081ENST00000373487Q5JS98
ENSG00000167081ENST00000373489P40426
ENSG00000167081ENST00000373492H3BLX0
ENSG00000167081ENST00000428092H0Y5D0
ENSG00000167081ENST00000447726P40426
ENSG00000167081ENST00000491787U3KQA2

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
222514802012Up-regulation of a HOXA-PBX3 homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis in patients with cytogenetically abnormal AML.75
232645952013PBX3 is an important cofactor of HOXA9 in leukemogenesis.45
215489402011Regulation of PBX3 expression by androgen and Let-7d in prostate cancer.30
255617932014PBX3 promotes migration and invasion of colorectal cancer cells via activation of MAPK/ERK signaling pathway.26
264200652015PBX3 is targeted by multiple miRNAs and is essential for liver tumour-initiating cells.24
231617752013MicroRNA profiling in pediatric pilocytic astrocytoma reveals biologically relevant targets, including PBX3, NFIB, and METAP2.23
281113402017MicroRNA-144-3p suppresses gastric cancer progression by inhibiting epithelial-to-mesenchymal transition through targeting PBX3.21
270868522016miR-320a regulates cell proliferation and apoptosis in multiple myeloma by targeting pre-B-cell leukemia transcription factor 3.18
272857592016MicroRNA-33a-3p suppresses cell migration and invasion by directly targeting PBX3 in human hepatocellular carcinoma.18

Citation

Dessen P

PBX3 (PBX homeobox 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41648/pbx3-(pbx-homeobox-3)