KAT2B (lysine acetyltransferase 2B)

2003-02-01 Affiliation

Identity

HGNC

KAT2B

LOCATION

3p24.3

LOCUSID

8850

ALIAS

CAF,P/CAF,PCAF

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 8850
MIM: 602303
HGNC: 8638
Ensembl: ENSG00000114166

Variants:

dbSNP: 8850
ClinVar: 8850
TCGA: ENSG00000114166
COSMIC: KAT2B

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000114166	ENST00000263754	Q92831

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Notch signaling pathway	KEGG	ko04330
Notch signaling pathway	KEGG	hsa04330
HTLV-I infection	KEGG	ko05166
HTLV-I infection	KEGG	hsa05166
Viral carcinogenesis	KEGG	hsa05203
Viral carcinogenesis	KEGG	ko05203
Thyroid hormone signaling pathway	KEGG	hsa04919
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Disease	REACTOME	R-HSA-1643685
Diseases of signal transduction	REACTOME	R-HSA-5663202
Signaling by NOTCH1 in Cancer	REACTOME	R-HSA-2644603
Signaling by NOTCH1 PEST Domain Mutants in Cancer	REACTOME	R-HSA-2644602
Constitutive Signaling by NOTCH1 PEST Domain Mutants	REACTOME	R-HSA-2644606
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	REACTOME	R-HSA-2894858
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	REACTOME	R-HSA-2894862
Signal Transduction	REACTOME	R-HSA-162582
Signaling by NOTCH	REACTOME	R-HSA-157118
Pre-NOTCH Expression and Processing	REACTOME	R-HSA-1912422
Pre-NOTCH Transcription and Translation	REACTOME	R-HSA-1912408
Signaling by NOTCH1	REACTOME	R-HSA-1980143
NOTCH1 Intracellular Domain Regulates Transcription	REACTOME	R-HSA-2122947
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Notch-HLH transcription pathway	REACTOME	R-HSA-350054
YAP1- and WWTR1 (TAZ)-stimulated gene expression	REACTOME	R-HSA-2032785
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription	REACTOME	R-HSA-504046
RNA Polymerase I Transcription	REACTOME	R-HSA-73864
RNA Polymerase I Promoter Clearance	REACTOME	R-HSA-73854
RNA Polymerase I Transcription Initiation	REACTOME	R-HSA-73762
Epigenetic regulation of gene expression	REACTOME	R-HSA-212165
Muscle contraction	REACTOME	R-HSA-397014
Chromatin organization	REACTOME	R-HSA-4839726
Chromatin modifying enzymes	REACTOME	R-HSA-3247509
HATs acetylate histones	REACTOME	R-HSA-3214847
Cardiac conduction	REACTOME	R-HSA-5576891
Physiological factors	REACTOME	R-HSA-5578768
Positive epigenetic regulation of rRNA expression	REACTOME	R-HSA-5250913
B-WICH complex positively regulates rRNA expression	REACTOME	R-HSA-5250924
Deubiquitination	REACTOME	R-HSA-5688426
Metalloprotease DUBs	REACTOME	R-HSA-5689901

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD
PA131890620	cannabinoids	Chemical	ClinicalAnnotation	associated	PD
PA446876	Substance-Related Disorders	Disease	ClinicalAnnotation	associated	PD
PA448408	amphetamine	Chemical	ClinicalAnnotation	associated	PD
PA449072	cocaine	Chemical	ClinicalAnnotation	associated	PD
PA452618	opioids	Chemical	ClinicalAnnotation	associated	PD

References

Pubmed ID	Year	Title	Citations
19996091	2010	Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization.	153
15572685	2004	The c-MYC oncoprotein is a substrate of the acetyltransferases hGCN5/PCAF and TIP60.	125
17908689	2007	Kruppel-like factor 4 is acetylated by p300 and regulates gene transcription via modulation of histone acetylation.	93
18838386	2008	Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein.	87
17293853	2007	Intrinsic ubiquitination activity of PCAF controls the stability of the oncoprotein Hdm2.	71
18400184	2008	Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300.	68
18599479	2008	An interaction between the human T cell leukemia virus type 1 basic leucine zipper factor (HBZ) and the KIX domain of p300/CBP contributes to the down-regulation of tax-dependent viral transcription by HBZ.	68
22055187	2011	SAGA and ATAC histone acetyl transferase complexes regulate distinct sets of genes and ATAC defines a class of p300-independent enhancers.	63
16096645	2005	Acetylation of HIV-1 integrase by p300 regulates viral integration.	62
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62

Citation

Dessen P

KAT2B (lysine acetyltransferase 2B)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41654/kat2b