PCM1 (pericentriolar material 1)

2003-02-01  

Identity

HGNC
LOCATION
8p22
LOCUSID
ALIAS
PTC4,RET/PCM-1
FUSION GENES

Other Information

Locus ID:

NCBI: 5108
MIM: 600299
HGNC: 8727
Ensembl: ENSG00000078674

Variants:

dbSNP: 5108
ClinVar: 5108
TCGA: ENSG00000078674
COSMIC: PCM1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000078674ENST00000325083Q15154
ENSG00000078674ENST00000327578A0A4W8VX11
ENSG00000078674ENST00000517730E7EV93
ENSG00000078674ENST00000518537E9PGW9
ENSG00000078674ENST00000522275H0YBA1
ENSG00000078674ENST00000523055E5RGQ4
ENSG00000078674ENST00000524226A0A4W8VX11

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Anchoring of the basal body to the plasma membraneREACTOMER-HSA-5620912
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942
Centrosome maturationREACTOMER-HSA-380287
Recruitment of mitotic centrosome proteins and complexesREACTOMER-HSA-380270
Loss of proteins required for interphase microtubule organization from the centrosomeREACTOMER-HSA-380284
Loss of Nlp from mitotic centrosomesREACTOMER-HSA-380259
AURKA Activation by TPX2REACTOMER-HSA-8854518

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
187721922008CEP290 interacts with the centriolar satellite component PCM-1 and is required for Rab8 localization to the primary cilium.144
187625862008Recruitment of PCM1 to the centrosome by the cooperative action of DISC1 and BBS4: a candidate for psychiatric illnesses.63
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
233454022013PCM1 recruits Plk1 to the pericentriolar matrix to promote primary cilia disassembly before mitotic entry.52
219857832011Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease.51
201521262010Hook3 interacts with PCM1 to regulate pericentriolar material assembly and the timing of neurogenesis.44
156596512005Dynamic recruitment of Nek2 kinase to the centrosome involves microtubules, PCM-1, and localized proteasomal degradation.39
207340642010A large-scale candidate gene association study of age at menarche and age at natural menopause.38
219981992011Hook2 is involved in the morphogenesis of the primary cilium.33
168940602006Genetic association and brain morphology studies and the chromosome 8p22 pericentriolar material 1 (PCM1) gene in susceptibility to schizophrenia.32

Citation

Dessen P

PCM1 (pericentriolar material 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41668/pcm1-(pericentriolar-material-1)