PDCD1 (programmed cell death 1)

2003-02-01  

Identity

HGNC
LOCATION
2q37.3
LOCUSID
ALIAS
CD279,PD-1,PD1,SLEB2,hPD-1,hPD-l,hSLE1

Other Information

Locus ID:

NCBI: 5133
MIM: 600244
HGNC: 8760
Ensembl: ENSG00000188389

Variants:

dbSNP: 5133
ClinVar: 5133
TCGA: ENSG00000188389
COSMIC: PDCD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000188389ENST00000334409Q15116
ENSG00000188389ENST00000334409A0A0M3M0G7
ENSG00000188389ENST00000343705H0Y2W6
ENSG00000188389ENST00000418831E7ER21

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
T cell receptor signaling pathwayKEGGko04660
Cell adhesion molecules (CAMs)KEGGhsa04514
T cell receptor signaling pathwayKEGGhsa04660
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Costimulation by the CD28 familyREACTOMER-HSA-388841
PD-1 signalingREACTOMER-HSA-389948

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
181733752008PD-1 and its ligands in tolerance and immunity.1482
247147712014Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy.698
169174892006Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction.638
206368202010The PD-1 pathway in tolerance and autoimmunity.604
162276042005CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms.524
194237282009Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired.506
257044392015Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single-arm trial.430
208199232010Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients.419
169543722006PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection.393
288353862017Tumor Mutational Burden as an Independent Predictor of Response to Immunotherapy in Diverse Cancers.341

Citation

Dessen P

PDCD1 (programmed cell death 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41673/pdcd1-(programmed-cell-death-1)