PIK3C2A (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha)

2003-06-01  

Identity

HGNC
LOCATION
11p15.1
LOCUSID
ALIAS
CPK,OCSKD,PI3-K-C2(ALPHA),PI3-K-C2A,PI3K-C2-alpha,PI3K-C2alpha
FUSION GENES

Other Information

Locus ID:

NCBI: 5286
MIM: 603601
HGNC: 8971
Ensembl: ENSG00000011405

Variants:

dbSNP: 5286
ClinVar: 5286
TCGA: ENSG00000011405
COSMIC: PIK3C2A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000011405ENST00000265970O00443
ENSG00000011405ENST00000265970L7RRS0
ENSG00000011405ENST00000532035E9PPP3
ENSG00000011405ENST00000533645A0A0C4DGF9

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Inositol phosphate metabolismKEGGko00562
Phosphatidylinositol signaling systemKEGGko04070
Inositol phosphate metabolismKEGGhsa00562
Phosphatidylinositol signaling systemKEGGhsa04070
Metabolic pathwaysKEGGhsa01100
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
trans-Golgi Network Vesicle BuddingREACTOMER-HSA-199992
Clathrin derived vesicle buddingREACTOMER-HSA-421837
Golgi Associated Vesicle BiogenesisREACTOMER-HSA-432722
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
PI MetabolismREACTOMER-HSA-1483255
Synthesis of PIPs at the Golgi membraneREACTOMER-HSA-1660514
Synthesis of PIPs at the plasma membraneREACTOMER-HSA-1660499
Synthesis of PIPs at the early endosome membraneREACTOMER-HSA-1660516
Synthesis of PIPs at the late endosome membraneREACTOMER-HSA-1660517
Clathrin-mediated endocytosisREACTOMER-HSA-8856828

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA134941638FGFR1OPGenePathwayassociated20124951
PA134972108FGFR1OP2GenePathwayassociated20124951
PA24684AKT1GenePathwayassociated20124951, 28362716
PA24685AKT2GenePathwayassociated20124951
PA24686AKT3GenePathwayassociated20124951
PA28127FGFR1GenePathwayassociated20124951
PA28128FGFR2GenePathwayassociated20124951
PA28129FGFR3GenePathwayassociated20124951
PA28130FGFR4GenePathwayassociated20124951
PA28131FGFR3P1GenePathwayassociated20124951
PA28132FGFRL1GenePathwayassociated20124951
PA28180FLT1GenePathwayassociated28362716
PA28183FLT4GenePathwayassociated28362716
PA29457HRH2GenePathwayassociated
PA30086KDRGenePathwayassociated28362716

References

Pubmed IDYearTitleCitations
192618492009Integrated genomic profiling of endometrial carcinoma associates aggressive tumors with indicators of PI3 kinase activation.105
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
176445132007The role of phosphoinositide 3-kinase C2alpha in insulin signaling.57
147296122004Nickel compounds act through phosphatidylinositol-3-kinase/Akt-dependent, p70(S6k)-independent pathway to induce hypoxia inducible factor transactivation and Cap43 expression in mouse epidermal Cl41 cells.23
170383102006Structural and membrane binding analysis of the Phox homology domain of phosphoinositide 3-kinase-C2alpha.23
204530002010A Large-scale genetic association study of esophageal adenocarcinoma risk.23
162152322005Individual phosphoinositide 3-kinase C2alpha domain activities independently regulate clathrin function.18
184036402008Down-regulation of class II phosphoinositide 3-kinase alpha expression below a critical threshold induces apoptotic cell death.18
231923422013Essential role of class II phosphatidylinositol-3-kinase-C2α in sphingosine 1-phosphate receptor-1-mediated signaling and migration in endothelial cells.17
151838932004Vascular endothelial growth factor receptor-1 and receptor-2 initiate a phosphatidylinositide 3-kinase-dependent clonogenic response in acute myeloid leukemia cells.16

Citation

Dessen P

PIK3C2A (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41711/pik3c2a