PIK3C3 (phosphatidylinositol 3-kinase catalytic subunit type 3)

2003-11-01  

Identity

HGNC
LOCATION
18q12.3
LOCUSID
ALIAS
VPS34,Vps34,hVps34
FUSION GENES

Other Information

Locus ID:

NCBI: 5289
MIM: 602609
HGNC: 8974
Ensembl: ENSG00000078142

Variants:

dbSNP: 5289
ClinVar: 5289
TCGA: ENSG00000078142
COSMIC: PIK3C3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000078142ENST00000262039Q8NEB9
ENSG00000078142ENST00000398870A8MYT4
ENSG00000078142ENST00000585528K7EIV6
ENSG00000078142ENST00000586545K7EKH3
ENSG00000078142ENST00000587402M0R386
ENSG00000078142ENST00000589056A0A0B4J2B1
ENSG00000078142ENST00000591011K7ENH3
ENSG00000078142ENST00000597477M0R308
ENSG00000078142ENST00000639914A0A1W2PS05

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Inositol phosphate metabolismKEGGko00562
Phosphatidylinositol signaling systemKEGGko04070
Autophagy - animalKEGGko04140
Inositol phosphate metabolismKEGGhsa00562
Phosphatidylinositol signaling systemKEGGhsa04070
Autophagy - animalKEGGhsa04140
Metabolic pathwaysKEGGhsa01100
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Toll Like Receptor 9 (TLR9) CascadeREACTOMER-HSA-168138
Signal TransductionREACTOMER-HSA-162582
Signaling by Insulin receptorREACTOMER-HSA-74752
Insulin receptor signalling cascadeREACTOMER-HSA-74751
IRS-mediated signallingREACTOMER-HSA-112399
PI3K CascadeREACTOMER-HSA-109704
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate NADPH OxidasesREACTOMER-HSA-5668599
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)REACTOMER-HSA-2404192
IGF1R signaling cascadeREACTOMER-HSA-2428924
IRS-related events triggered by IGF1RREACTOMER-HSA-2428928
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
PI MetabolismREACTOMER-HSA-1483255
Synthesis of PIPs at the Golgi membraneREACTOMER-HSA-1660514
Synthesis of PIPs at the early endosome membraneREACTOMER-HSA-1660516
Synthesis of PIPs at the late endosome membraneREACTOMER-HSA-1660517
Cellular responses to stressREACTOMER-HSA-2262752
MacroautophagyREACTOMER-HSA-1632852
Apelin signaling pathwayKEGGhsa04371
Autophagy - otherKEGGko04136
Autophagy - otherKEGGhsa04136

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
161769822005Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.275
160490092005hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase.178
168740272005The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function.157
180774262007Runs of homozygosity reveal highly penetrant recessive loci in schizophrenia.131
163908692006Functional specificity of the mammalian Beclin-Vps34 PI 3-kinase complex in macroautophagy versus endocytosis and lysosomal enzyme trafficking.129
129256802003Tuberculosis toxin blocking phagosome maturation inhibits a novel Ca2+/calmodulin-PI3K hVPS34 cascade.101
240132182013Regulation of PIK3C3/VPS34 complexes by MTOR in nutrient stress-induced autophagy.80
206431232010A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic.79
187255402008SopB promotes phosphatidylinositol 3-phosphate formation on Salmonella vacuoles by recruiting Rab5 and Vps34.74
218357922011Rab5 and class III phosphoinositide 3-kinase Vps34 are involved in hepatitis C virus NS4B-induced autophagy.72

Citation

Dessen P

PIK3C3 (phosphatidylinositol 3-kinase catalytic subunit type 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41714/pik3c3-(phosphatidylinositol-3-kinase-catalytic-subunit-type-3)