PIR (pirin)

2003-05-01  

Identity

HGNC
LOCATION
Xp22.2
LOCUSID

Other Information

Locus ID:

NCBI: 8544
MIM: 300931
HGNC: 30048
Ensembl: ENSG00000087842

Variants:

dbSNP: 8544
ClinVar: 8544
TCGA: ENSG00000087842
COSMIC: PIR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000087842ENST00000380420O00625
ENSG00000087842ENST00000380420A0A024RBX6
ENSG00000087842ENST00000380421O00625
ENSG00000087842ENST00000380421A0A024RBX6

Expression (GTEx)

0
5
10
15
20
25
30

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
145735962004Crystal structure of human pirin: an iron-binding nuclear protein and transcription cofactor.34
159515722005Structural and biochemical analysis reveal pirins to possess quercetinase activity.23
207111962010A small-molecule inhibitor shows that pirin regulates migration of melanoma cells.23
237166612013Pirin is an iron-dependent redox regulator of NF-κB.23
215144502011Pirin inhibits cellular senescence in melanocytic cells.14
200106242010Pirin downregulation is a feature of AML and leads to impairment of terminal myeloid differentiation.11
256805272015Pirin regulates epithelial to mesenchymal transition independently of Bcl3-Slug signaling.11
304440382019Pirin: a potential novel therapeutic target for castration-resistant prostate cancer regulated by miR-455-5p.11
200891662010Pirin delocalization in melanoma progression identified by high content immuno-detection based approaches.9
243900862014Basal PIR expression in HeLa cells is driven by NRF2 via evolutionary conserved antioxidant response element.8

Citation

Dessen P

PIR (pirin)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41722/pir-(pirin)