RAD51AP1 (RAD51 associated protein 1)

2003-11-01  

Identity

HGNC
RAD51AP1
LOCATION
12p13.32
LOCUSID
10635
ALIAS
PIR51
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10635
MIM: 603070
HGNC: 16956
Ensembl: ENSG00000111247

Variants:

dbSNP: 10635
ClinVar: 10635
TCGA: ENSG00000111247
COSMIC: RAD51AP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111247ENST00000228843Q96B01
ENSG00000111247ENST00000352618Q96B01
ENSG00000111247ENST00000398012F5H4V6
ENSG00000111247ENST00000442992F5H4V6
ENSG00000111247ENST00000535558F5H031
ENSG00000111247ENST00000536117H0YGT5
ENSG00000111247ENST00000536346F5H4V6
ENSG00000111247ENST00000536886F5H031
ENSG00000111247ENST00000538817F5H710
ENSG00000111247ENST00000544110F5H4V6
ENSG00000111247ENST00000544173H0YFK6
ENSG00000111247ENST00000544927F5H1Y0

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
HDR through Homologous Recombination (HRR)REACTOMER-HSA-5685942
Homologous DNA Pairing and Strand ExchangeREACTOMER-HSA-5693579
Resolution of D-Loop StructuresREACTOMER-HSA-5693537
Resolution of D-loop Structures through Holliday Junction IntermediatesREACTOMER-HSA-5693568
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)REACTOMER-HSA-5693554

References

Pubmed IDYearTitleCitations
384032482024Pre-rRNA facilitates the recruitment of RAD51AP1 to DNA double-strand breaks.0
384032482024Pre-rRNA facilitates the recruitment of RAD51AP1 to DNA double-strand breaks.0
372834902023Identification of the E2F1-RAD51AP1 axis as a key factor in MGMT-methylated GBM TMZ resistance.2
379628622023The gene RAD51AP1 promotes the progression of pancreatic cancer via the PI3K/Akt/NF-κB signaling pathway.0
372834902023Identification of the E2F1-RAD51AP1 axis as a key factor in MGMT-methylated GBM TMZ resistance.2
379628622023The gene RAD51AP1 promotes the progression of pancreatic cancer via the PI3K/Akt/NF-κB signaling pathway.0
331728952021A Novel Neoplastic Fusion Transcript, RAD51AP1-DYRK4, Confers Sensitivity to the MEK Inhibitor Trametinib in Aggressive Breast Cancers.9
333145672021RAD51AP1 promotes progression of ovarian cancer via TGF-β/Smad signalling pathway.13
340581982021RAD51AP1 mediates RAD51 activity through nucleosome interaction.5
340978592021ZEB1 induces non-small cell lung cancer development by targeting microRNA-320a to increase the expression of RAD51AP1.3
340995222021RAD51AP1 Loss Attenuates Colorectal Cancer Stem Cell Renewal and Sensitizes to Chemotherapy.11
331728952021A Novel Neoplastic Fusion Transcript, RAD51AP1-DYRK4, Confers Sensitivity to the MEK Inhibitor Trametinib in Aggressive Breast Cancers.9
333145672021RAD51AP1 promotes progression of ovarian cancer via TGF-β/Smad signalling pathway.13
340581982021RAD51AP1 mediates RAD51 activity through nucleosome interaction.5
340978592021ZEB1 induces non-small cell lung cancer development by targeting microRNA-320a to increase the expression of RAD51AP1.3

Citation

Dessen P

RAD51AP1 (RAD51 associated protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41723/favicon/js/lib/popper.js