PPP1CB (protein phosphatase 1 catalytic subunit beta)

2003-11-01  

Identity

HGNC
LOCATION
2p23.2
LOCUSID
ALIAS
HEL-S-80p,MP,NSLH2,PP-1B,PP1B,PP1beta,PP1c,PPP1CD,PPP1beta
FUSION GENES

Other Information

Locus ID:

NCBI: 5500
MIM: 600590
HGNC: 9282
Ensembl: ENSG00000213639

Variants:

dbSNP: 5500
ClinVar: 5500
TCGA: ENSG00000213639
COSMIC: PPP1CB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000213639ENST00000296122P62140
ENSG00000213639ENST00000296122V9HW04
ENSG00000213639ENST00000358506P62140
ENSG00000213639ENST00000358506V9HW04
ENSG00000213639ENST00000395366P62140
ENSG00000213639ENST00000395366V9HW04
ENSG00000213639ENST00000418910H0Y3Y6
ENSG00000213639ENST00000420282C9J9S3
ENSG00000213639ENST00000427786F8WE71
ENSG00000213639ENST00000441461C9JP48
ENSG00000213639ENST00000455580E7ETD8

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
Focal adhesionKEGGko04510
Long-term potentiationKEGGko04720
Regulation of actin cytoskeletonKEGGko04810
Insulin signaling pathwayKEGGko04910
Focal adhesionKEGGhsa04510
Long-term potentiationKEGGhsa04720
Regulation of actin cytoskeletonKEGGhsa04810
Insulin signaling pathwayKEGGhsa04910
Vascular smooth muscle contractionKEGGhsa04270
Vascular smooth muscle contractionKEGGko04270
Oocyte meiosisKEGGko04114
Oocyte meiosisKEGGhsa04114
mRNA surveillance pathwayKEGGko03015
mRNA surveillance pathwayKEGGhsa03015
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Dopaminergic synapseKEGGko04728
Dopaminergic synapseKEGGhsa04728
Amphetamine addictionKEGGhsa05031
Amphetamine addictionKEGGko05031
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Adrenergic signaling in cardiomyocytesKEGGhsa04261
Adrenergic signaling in cardiomyocytesKEGGko04261
Inflammatory mediator regulation of TRP channelsKEGGhsa04750
Inflammatory mediator regulation of TRP channelsKEGGko04750
Platelet activationKEGGhsa04611
Oxytocin signaling pathwayKEGGhsa04921
Oxytocin signaling pathwayKEGGko04921
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ROCKsREACTOMER-HSA-5627117
RHO GTPases activate PAKsREACTOMER-HSA-5627123
RHO GTPases activate PKNsREACTOMER-HSA-5625740
Signaling by TGF-beta Receptor ComplexREACTOMER-HSA-170834
TGF-beta receptor signaling activates SMADsREACTOMER-HSA-2173789
Downregulation of TGF-beta receptor signalingREACTOMER-HSA-2173788
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942
Circadian ClockREACTOMER-HSA-400253
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Lipid digestion, mobilization, and transportREACTOMER-HSA-73923
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysisREACTOMER-HSA-163560
Insulin resistanceKEGGhsa04931

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
334918562021Noonan syndrome with loose anagen hair with variants in the PPP1CB gene: First familial case reported.4
341250042021The expression and clinical prognostic value of protein phosphatase 1 catalytic subunit beta in pancreatic cancer.0
344250332021PP-1β and PP-2Aα modulate cAMP response element-binding protein (CREB) functions in aging control and stress response through de-regulation of αB-crystallin gene and p300-p53 signaling axis.6
334918562021Noonan syndrome with loose anagen hair with variants in the PPP1CB gene: First familial case reported.4
341250042021The expression and clinical prognostic value of protein phosphatase 1 catalytic subunit beta in pancreatic cancer.0
344250332021PP-1β and PP-2Aα modulate cAMP response element-binding protein (CREB) functions in aging control and stress response through de-regulation of αB-crystallin gene and p300-p53 signaling axis.6
311085002020Activating MRAS mutations cause Noonan syndrome associated with hypertrophic cardiomyopathy.21
322669262020Integrative genomics analysis of eQTL and GWAS summary data identifies PPP1CB as a novel bone mineral density risk genes.0
324762862020A case report of Noonan syndrome-like disorder with loose anagen hair 2 treated with recombinant human growth hormone.1
311085002020Activating MRAS mutations cause Noonan syndrome associated with hypertrophic cardiomyopathy.21
322669262020Integrative genomics analysis of eQTL and GWAS summary data identifies PPP1CB as a novel bone mineral density risk genes.0
324762862020A case report of Noonan syndrome-like disorder with loose anagen hair 2 treated with recombinant human growth hormone.1
303686682019Delineation of LZTR1 mutation-positive patients with Noonan syndrome and identification of LZTR1 binding to RAF1-PPP1CB complexes.34
313159272019TIMAP inhibits endothelial myosin light chain phosphatase by competing with MYPT1 for the catalytic protein phosphatase 1 subunit PP1cβ.6
313234362019HOXA2 activity regulation by cytoplasmic relocation, protein stabilization and post-translational modification.2

Citation

Dessen P

PPP1CB (protein phosphatase 1 catalytic subunit beta)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41805/css/js/lib/css/lib/bootstrap.min.css