PPP1CB (protein phosphatase 1 catalytic subunit beta)

2003-11-01 Affiliation

Identity

HGNC

PPP1CB

LOCATION

2p23.2

LOCUSID

5500

ALIAS

HEL-S-80p,MP,NSLH2,PP-1B,PP1B,PP1beta,PP1c,PPP1CD,PPP1beta

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5500
MIM: 600590
HGNC: 9282
Ensembl: ENSG00000213639

Variants:

dbSNP: 5500
ClinVar: 5500
TCGA: ENSG00000213639
COSMIC: PPP1CB

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000213639	ENST00000296122	P62140
ENSG00000213639	ENST00000296122	V9HW04
ENSG00000213639	ENST00000358506	P62140
ENSG00000213639	ENST00000358506	V9HW04
ENSG00000213639	ENST00000395366	P62140
ENSG00000213639	ENST00000395366	V9HW04
ENSG00000213639	ENST00000418910	H0Y3Y6
ENSG00000213639	ENST00000420282	C9J9S3
ENSG00000213639	ENST00000427786	F8WE71
ENSG00000213639	ENST00000441461	C9JP48
ENSG00000213639	ENST00000455580	E7ETD8

Expression (GTEx)

100

150

200

250

300

350

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Focal adhesion	KEGG	ko04510
Long-term potentiation	KEGG	ko04720
Regulation of actin cytoskeleton	KEGG	ko04810
Insulin signaling pathway	KEGG	ko04910
Focal adhesion	KEGG	hsa04510
Long-term potentiation	KEGG	hsa04720
Regulation of actin cytoskeleton	KEGG	hsa04810
Insulin signaling pathway	KEGG	hsa04910
Vascular smooth muscle contraction	KEGG	hsa04270
Vascular smooth muscle contraction	KEGG	ko04270
Oocyte meiosis	KEGG	ko04114
Oocyte meiosis	KEGG	hsa04114
mRNA surveillance pathway	KEGG	ko03015
mRNA surveillance pathway	KEGG	hsa03015
Herpes simplex infection	KEGG	ko05168
Herpes simplex infection	KEGG	hsa05168
Dopaminergic synapse	KEGG	ko04728
Dopaminergic synapse	KEGG	hsa04728
Amphetamine addiction	KEGG	hsa05031
Amphetamine addiction	KEGG	ko05031
Alcoholism	KEGG	hsa05034
Alcoholism	KEGG	ko05034
Hippo signaling pathway	KEGG	hsa04390
Hippo signaling pathway	KEGG	ko04390
Proteoglycans in cancer	KEGG	hsa05205
Proteoglycans in cancer	KEGG	ko05205
Adrenergic signaling in cardiomyocytes	KEGG	hsa04261
Adrenergic signaling in cardiomyocytes	KEGG	ko04261
Inflammatory mediator regulation of TRP channels	KEGG	hsa04750
Inflammatory mediator regulation of TRP channels	KEGG	ko04750
Platelet activation	KEGG	hsa04611
Oxytocin signaling pathway	KEGG	hsa04921
Oxytocin signaling pathway	KEGG	ko04921
cGMP-PKG signaling pathway	KEGG	hsa04022
cGMP-PKG signaling pathway	KEGG	ko04022
cAMP signaling pathway	KEGG	hsa04024
cAMP signaling pathway	KEGG	ko04024
Signal Transduction	REACTOME	R-HSA-162582
Signaling by Rho GTPases	REACTOME	R-HSA-194315
RHO GTPase Effectors	REACTOME	R-HSA-195258
RHO GTPases Activate ROCKs	REACTOME	R-HSA-5627117
RHO GTPases activate PAKs	REACTOME	R-HSA-5627123
RHO GTPases activate PKNs	REACTOME	R-HSA-5625740
Signaling by TGF-beta Receptor Complex	REACTOME	R-HSA-170834
TGF-beta receptor signaling activates SMADs	REACTOME	R-HSA-2173789
Downregulation of TGF-beta receptor signaling	REACTOME	R-HSA-2173788
Cell Cycle	REACTOME	R-HSA-1640170
Cell Cycle, Mitotic	REACTOME	R-HSA-69278
Mitotic G2-G2/M phases	REACTOME	R-HSA-453274
G2/M Transition	REACTOME	R-HSA-69275
Regulation of PLK1 Activity at G2/M Transition	REACTOME	R-HSA-2565942
Circadian Clock	REACTOME	R-HSA-400253
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Lipid digestion, mobilization, and transport	REACTOME	R-HSA-73923
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis	REACTOME	R-HSA-163560
Insulin resistance	KEGG	hsa04931

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
22360570	2013	The PP1 binding code: a molecular-lego strategy that governs specificity.	93
22284538	2013	Structural basis for protein phosphatase 1 regulation and specificity.	74
20516061	2010	Identification and characterization of a novel human PP1 phosphatase complex.	38
22299668	2013	PP1 and PP2A phosphatases--cooperating partners in modulating retinoblastoma protein activation.	35
20186153	2010	Protein phosphatase-1 regulates Akt1 signal transduction pathway to control gene expression, cell survival and differentiation.	29
27264673	2016	A novel rasopathy caused by recurrent de novo missense mutations in PPP1CB closely resembles Noonan syndrome with loose anagen hair.	24
19124506	2009	Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer.	22
26334248	2015	Cardiac-specific deletion of protein phosphatase 1β promotes increased myofilament protein phosphorylation and contractile alterations.	20
18202305	2008	PPP1R16A, the membrane subunit of protein phosphatase 1beta, signals nuclear translocation of the nuclear receptor constitutive active/androstane receptor.	19
21795688	2011	Rapid dephosphorylation of G protein-coupled receptors by protein phosphatase 1β is required for termination of β-arrestin-dependent signaling.	16

Citation

Dessen P

PPP1CB (protein phosphatase 1 catalytic subunit beta)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41805/ppp1cb