PPP6C (protein phosphatase 6 catalytic subunit)

2003-11-01  

Identity

HGNC
PPP6C
LOCATION
9q33.3
LOCUSID
5537
ALIAS
PP6,PP6C
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5537
MIM: 612725
HGNC: 9323
Ensembl: ENSG00000119414

Variants:

dbSNP: 5537
ClinVar: 5537
TCGA: ENSG00000119414
COSMIC: PPP6C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000119414ENST00000373547O00743
ENSG00000119414ENST00000373547A0A024R861
ENSG00000119414ENST00000415905O00743
ENSG00000119414ENST00000451402O00743
ENSG00000119414ENST00000456642Q5T1S7

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
COPII (Coat Protein 2) Mediated Vesicle TransportREACTOMER-HSA-204005
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
387452652024M6A-induced transcription factor IRF5 contributes to the progression of cervical cancer by upregulating PPP6C.0
387452652024M6A-induced transcription factor IRF5 contributes to the progression of cervical cancer by upregulating PPP6C.0
360710402022PP6 negatively modulates LUBAC-mediated M1-ubiquitination of RIPK1 and c-FLIP(L) to promote TNFα-mediated cell death.5
360710402022PP6 negatively modulates LUBAC-mediated M1-ubiquitination of RIPK1 and c-FLIP(L) to promote TNFα-mediated cell death.5
337891172021PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK.17
343144862021Protein phosphatase 6 promotes neurite outgrowth by promoting mTORC2 activity in N2a cells.3
345871642021MiR-20a-5p functions as a potent tumor suppressor by targeting PPP6C in acute myeloid leukemia.5
337891172021PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK.17
343144862021Protein phosphatase 6 promotes neurite outgrowth by promoting mTORC2 activity in N2a cells.3
345871642021MiR-20a-5p functions as a potent tumor suppressor by targeting PPP6C in acute myeloid leukemia.5
324747002020Dephosphorylation of cGAS by PPP6C impairs its substrate binding activity and innate antiviral response.25
327534992020PPP6C Negatively Regulates STING-Dependent Innate Immune Responses.19
324747002020Dephosphorylation of cGAS by PPP6C impairs its substrate binding activity and innate antiviral response.25
327534992020PPP6C Negatively Regulates STING-Dependent Innate Immune Responses.19
295394112018A PP6-ASK3 Module Coordinates the Bidirectional Cell Volume Regulation under Osmotic Stress.15

Citation

Dessen P

PPP6C (protein phosphatase 6 catalytic subunit)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41826/js/lib/favicon/favicon-16x16.png