PRKAR1B (protein kinase cAMP-dependent type I regulatory subunit beta)

2003-11-01  

Identity

HGNC
LOCATION
7p22.3
LOCUSID
ALIAS
PRKAR1
FUSION GENES

Other Information

Locus ID:

NCBI: 5575
MIM: 176911
HGNC: 9390
Ensembl: ENSG00000188191

Variants:

dbSNP: 5575
ClinVar: 5575
TCGA: ENSG00000188191
COSMIC: PRKAR1B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000188191ENST00000360274P31321
ENSG00000188191ENST00000400758H7BYW5
ENSG00000188191ENST00000403562P31321
ENSG00000188191ENST00000406797P31321
ENSG00000188191ENST00000414568C9JR00
ENSG00000188191ENST00000417852C9IZL8
ENSG00000188191ENST00000430040C9JSK5
ENSG00000188191ENST00000456696C9J4C2
ENSG00000188191ENST00000537384P31321
ENSG00000188191ENST00000544935P31321

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Insulin signaling pathwayKEGGko04910
Insulin signaling pathwayKEGGhsa04910
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
DAP12 interactionsREACTOMER-HSA-2172127
DAP12 signalingREACTOMER-HSA-2424491
DAG and IP3 signalingREACTOMER-HSA-1489509
CaM pathwayREACTOMER-HSA-111997
Calmodulin induced eventsREACTOMER-HSA-111933
PKA-mediated phosphorylation of CREBREACTOMER-HSA-111931
PKA activationREACTOMER-HSA-163615
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231
Signal TransductionREACTOMER-HSA-162582
Signaling by EGFRREACTOMER-HSA-177929
EGFR interacts with phospholipase C-gammaREACTOMER-HSA-212718
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
PLC-gamma1 signallingREACTOMER-HSA-167021
Signaling by PDGFREACTOMER-HSA-186797
Downstream signal transductionREACTOMER-HSA-186763
Signaling by GPCRREACTOMER-HSA-372790
Opioid SignallingREACTOMER-HSA-111885
G-protein mediated eventsREACTOMER-HSA-112040
PLC beta mediated eventsREACTOMER-HSA-112043
Ca-dependent eventsREACTOMER-HSA-111996
DARPP-32 eventsREACTOMER-HSA-180024
Signaling by HedgehogREACTOMER-HSA-5358351
Hedgehog 'off' stateREACTOMER-HSA-5610787
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Aquaporin-mediated transportREACTOMER-HSA-445717
Vasopressin regulates renal water homeostasis via AquaporinsREACTOMER-HSA-432040
MetabolismREACTOMER-HSA-1430728
Integration of energy metabolismREACTOMER-HSA-163685
Regulation of insulin secretionREACTOMER-HSA-422356
Glucagon-like Peptide-1 (GLP1) regulates insulin secretionREACTOMER-HSA-381676
Glucagon signaling in metabolic regulationREACTOMER-HSA-163359
PKA activation in glucagon signallingREACTOMER-HSA-164378

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203791462010Biological pathway-based genome-wide association analysis identified the vasoactive intestinal peptide (VIP) pathway important for obesity.22
247222522014PRKAR1B mutation associated with a new neurodegenerative disorder with unique pathology.12
205883082010Dengue hemorrhagic fever is associated with polymorphisms in JAK1.9
119437772002The paired-like homeodomain protein, Arix, mediates protein kinase A-stimulated dopamine beta-hydroxylase gene transcription through its phosphorylation status.5
126340562003A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system.4
251085592014Mutation frequency of PRKAR1B and the major familial dementia genes in a Dutch early onset dementia cohort.2

Citation

Dessen P

PRKAR1B (protein kinase cAMP-dependent type I regulatory subunit beta)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41850/prkar1b