PRKCE (protein kinase C epsilon)

2003-02-01  

Identity

HGNC
LOCATION
2p21
LOCUSID
ALIAS
PKCE,nPKC-epsilon
FUSION GENES

Other Information

Locus ID:

NCBI: 5581
MIM: 176975
HGNC: 9401
Ensembl: ENSG00000171132

Variants:

dbSNP: 5581
ClinVar: 5581
TCGA: ENSG00000171132
COSMIC: PRKCE

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171132ENST00000306156Q02156
ENSG00000171132ENST00000306156L7RTI5
ENSG00000171132ENST00000394874E9PBI2
ENSG00000171132ENST00000421201C9JR22

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Tight junctionKEGGko04530
Type II diabetes mellitusKEGGko04930
Tight junctionKEGGhsa04530
Type II diabetes mellitusKEGGhsa04930
Vascular smooth muscle contractionKEGGhsa04270
Vascular smooth muscle contractionKEGGko04270
Fc gamma R-mediated phagocytosisKEGGko04666
Fc gamma R-mediated phagocytosisKEGGhsa04666
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
Inflammatory mediator regulation of TRP channelsKEGGhsa04750
Inflammatory mediator regulation of TRP channelsKEGGko04750
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
Sphingolipid signaling pathwayKEGGhsa04071
Sphingolipid signaling pathwayKEGGko04071
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
Role of phospholipids in phagocytosisREACTOMER-HSA-2029485
DAP12 interactionsREACTOMER-HSA-2172127
DAP12 signalingREACTOMER-HSA-2424491
DAG and IP3 signalingREACTOMER-HSA-1489509
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Effects of PIP2 hydrolysisREACTOMER-HSA-114508
Signal TransductionREACTOMER-HSA-162582
Signaling by EGFRREACTOMER-HSA-177929
EGFR interacts with phospholipase C-gammaREACTOMER-HSA-212718
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
PLC-gamma1 signallingREACTOMER-HSA-167021
Signaling by PDGFREACTOMER-HSA-186797
Downstream signal transductionREACTOMER-HSA-186763
Signaling by ERBB2REACTOMER-HSA-1227986
SHC1 events in ERBB2 signalingREACTOMER-HSA-1250196
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (z) signalling eventsREACTOMER-HSA-418597
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Aldosterone synthesis and secretionKEGGhsa04925
Insulin resistanceKEGGhsa04931
Aldosterone synthesis and secretionKEGGko04925
AGE-RAGE signaling pathway in diabetic complicationsKEGGko04933
AGE-RAGE signaling pathway in diabetic complicationsKEGGhsa04933
Apelin signaling pathwayKEGGhsa04371

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA166122986radiotherapyChemicalClinicalAnnotationassociatedPD25054431
PA33392PLCG1GenePathwayassociated20124951
PA33393PLCG2GenePathwayassociated20124951
PA34183RAF1GenePathwayassociated20124951
PA39ADRB2GenePathwayassociated
PA62ATP1A1GenePathwayassociated23788015

References

Pubmed IDYearTitleCitations
118843852002Direct phosphorylation of capsaicin receptor VR1 by protein kinase Cepsilon and identification of two target serine residues.159
192441182009miR-205 Exerts tumor-suppressive functions in human prostate through down-regulation of protein kinase Cepsilon.143
196332922009Hyaluronan-CD44 interaction with protein kinase C(epsilon) promotes oncogenic signaling by the stem cell marker Nanog and the Production of microRNA-21, leading to down-regulation of the tumor suppressor protein PDCD4, anti-apoptosis, and chemotherapy resistance in breast tumor cells.121
182921832008Probiotics ameliorate the hydrogen peroxide-induced epithelial barrier disruption by a PKC- and MAP kinase-dependent mechanism.100
167939022006Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Cepsilon- and A-dependent mechanisms in rats and mice.96
198745742009Genetical genomic determinants of alcohol consumption in rats and humans.93
183193012008Cdc42- and Rac1-mediated endothelial lumen formation requires Pak2, Pak4 and Par3, and PKC-dependent signaling.92
231231962012EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes tumorigenesis.82
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
119348852002The anchoring protein RACK1 links protein kinase Cepsilon to integrin beta chains. Requirements for adhesion and motility.59

Citation

Dessen P

PRKCE (protein kinase C epsilon)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41855/prkce-(protein-kinase-c-epsilon)