PKN1 (protein kinase N1)

2003-11-01  

Identity

HGNC
PKN1
LOCATION
19p13.12
LOCUSID
5585
ALIAS
DBK,PAK-1,PAK1,PKN,PKN-ALPHA,PRK1,PRKCL1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5585
MIM: 601032
HGNC: 9405
Ensembl: ENSG00000123143

Variants:

dbSNP: 5585
ClinVar: 5585
TCGA: ENSG00000123143
COSMIC: PKN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000123143ENST00000242783Q16512
ENSG00000123143ENST00000342216Q16512
ENSG00000123143ENST00000585619K7EPK3
ENSG00000123143ENST00000586237K7EN76
ENSG00000123143ENST00000586557K7EKY9
ENSG00000123143ENST00000590097K7EM57
ENSG00000123143ENST00000591461K7EL10
ENSG00000123143ENST00000592960K7ES10

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Salmonella infectionKEGGko05132
Salmonella infectionKEGGhsa05132
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases activate PKNsREACTOMER-HSA-5625740
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3REACTOMER-HSA-5625886

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
355332532022Upregulation of PKN1 as a Prognosis Biomarker for Endometrial Cancer.0
355332532022Upregulation of PKN1 as a Prognosis Biomarker for Endometrial Cancer.0
319817972020Cyclin-dependent kinase 1-mediated phosphorylation of protein kinase N1 promotes anchorage-independent growth and migration.5
321275822020Novel roles of PRK1 and PRK2 in cilia and cancer biology.5
319817972020Cyclin-dependent kinase 1-mediated phosphorylation of protein kinase N1 promotes anchorage-independent growth and migration.5
321275822020Novel roles of PRK1 and PRK2 in cilia and cancer biology.5
307420642019Protein Kinase N1 control of androgen-responsive serum response factor action provides rationale for novel prostate cancer treatment strategy.6
310458902019Secretory Carcinoma of the Skin: Report of 6 Cases, Including a Case With a Novel NFIX-PKN1 Translocation.9
311254602019Characterization of the novel cardiolipin binding regions identified on the protease and lipid activated PKC-related kinase 1.3
307420642019Protein Kinase N1 control of androgen-responsive serum response factor action provides rationale for novel prostate cancer treatment strategy.6
310458902019Secretory Carcinoma of the Skin: Report of 6 Cases, Including a Case With a Novel NFIX-PKN1 Translocation.9
311254602019Characterization of the novel cardiolipin binding regions identified on the protease and lipid activated PKC-related kinase 1.3
282221722017RhoA promotes epidermal stem cell proliferation via PKN1-cyclin D1 signaling.10
288755012017The protein kinase C super-family member PKN is regulated by mTOR and influences differentiation during prostate cancer progression.19
282221722017RhoA promotes epidermal stem cell proliferation via PKN1-cyclin D1 signaling.10

Citation

Dessen P

PKN1 (protein kinase N1)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41858/js/lib/js/lib/css/lib/dataTables.bootstrap.min.css