PTK2B (protein tyrosine kinase 2 beta)

2003-11-01  

Identity

HGNC
LOCATION
8p21.2
LOCUSID
ALIAS
CADTK,CAKB,FADK2,FAK2,PKB,PTK,PYK2,RAFTK
FUSION GENES

Other Information

Locus ID:

NCBI: 2185
MIM: 601212
HGNC: 9612
Ensembl: ENSG00000120899

Variants:

dbSNP: 2185
ClinVar: 2185
TCGA: ENSG00000120899
COSMIC: PTK2B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120899ENST00000346049Q14289
ENSG00000120899ENST00000397501Q14289
ENSG00000120899ENST00000412793C9JHV9
ENSG00000120899ENST00000420218Q14289
ENSG00000120899ENST00000517339Q14289
ENSG00000120899ENST00000519512H0YB74
ENSG00000120899ENST00000521164E5RK84
ENSG00000120899ENST00000522338E5RHL2
ENSG00000120899ENST00000522517E5RJ77

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Natural killer cell mediated cytotoxicityKEGGko04650
Leukocyte transendothelial migrationKEGGko04670
GnRH signaling pathwayKEGGko04912
Calcium signaling pathwayKEGGhsa04020
Natural killer cell mediated cytotoxicityKEGGhsa04650
Leukocyte transendothelial migrationKEGGhsa04670
GnRH signaling pathwayKEGGhsa04912
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
Hepatitis BKEGGhsa05161
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-2 signalingREACTOMER-HSA-451927
Signal TransductionREACTOMER-HSA-162582
Signaling by VEGFREACTOMER-HSA-194138
VEGFA-VEGFR2 PathwayREACTOMER-HSA-4420097
Cell-Cell communicationREACTOMER-HSA-1500931
Signal regulatory protein (SIRP) family interactionsREACTOMER-HSA-391160
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
197180252009Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4.143
177858442007ICAM-1-mediated, Src- and Pyk2-dependent vascular endothelial cadherin tyrosine phosphorylation is required for leukocyte transendothelial migration.134
209669712010The FERM domain: organizing the structure and function of FAK.125
126065032003Regulation of PGC-1 promoter activity by protein kinase B and the forkhead transcription factor FKHR.90
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
224544202012Safety, pharmacokinetic, and pharmacodynamic phase I dose-escalation trial of PF-00562271, an inhibitor of focal adhesion kinase, in advanced solid tumors.84
177168642008PKB and the mitochondria: AKTing on apoptosis.70
159670962005The tyrosine kinase pyk2 promotes migration and invasion of glioma cells.62
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
175379192007Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis.55

Citation

Dessen P

PTK2B (protein tyrosine kinase 2 beta)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41899/ptk2b-(protein-tyrosine-kinase-2-beta)