PTPN12 (protein tyrosine phosphatase non-receptor type 12)

2003-02-01  

Identity

HGNC
LOCATION
7q11.23
LOCUSID
ALIAS
PTP-PEST,PTPG1
FUSION GENES

Other Information

Locus ID:

NCBI: 5782
MIM: 600079
HGNC: 9645
Ensembl: ENSG00000127947

Variants:

dbSNP: 5782
ClinVar: 5782
TCGA: ENSG00000127947
COSMIC: PTPN12

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000127947ENST00000248594Q05209
ENSG00000127947ENST00000407343H3BM04
ENSG00000127947ENST00000415482Q05209
ENSG00000127947ENST00000418110C9J1X8
ENSG00000127947ENST00000433369C9JJC1
ENSG00000127947ENST00000435495Q05209
ENSG00000127947ENST00000440186C9JYA4
ENSG00000127947ENST00000447995F8WB51
ENSG00000127947ENST00000522115H0YC15
ENSG00000127947ENST00000523952H0YB59

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by EGFRREACTOMER-HSA-177929
EGFR downregulationREACTOMER-HSA-182971
Signaling by PDGFREACTOMER-HSA-186797
Signaling by ERBB2REACTOMER-HSA-1227986
SHC1 events in ERBB2 signalingREACTOMER-HSA-1250196
Downregulation of ERBB2 signalingREACTOMER-HSA-8863795

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
213762332011Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase.109
218760012011Ras-induced and extracellular signal-regulated kinase 1 and 2 phosphorylation-dependent isomerization of protein tyrosine phosphatase (PTP)-PEST by PIN1 promotes FAK dephosphorylation by PTP-PEST.32
205194512010PTP-PEST controls motility, adherens junction assembly, and Rho GTPase activity in colon cancer cells.23
173293982007Interaction of Pyk2 and PTP-PEST with leupaxin in prostate cancer cells.21
244750462014Decreased expression of PTPN12 correlates with tumor recurrence and poor survival of patients with hepatocellular carcinoma.18
234354212014PTPN12 promotes resistance to oxidative stress and supports tumorigenesis by regulating FOXO signaling.15
224296742012Tyrosine-protein phosphatase nonreceptor type 12 is a novel prognostic biomarker for esophageal squamous cell carcinoma.14
214830992011Tyrosine phosphatases in the HER2-directed motility of ovarian cancer cells: Involvement of PTPN12, ERK5 and FAK.13
171302342007Caspase-3 regulates catalytic activity and scaffolding functions of the protein tyrosine phosphatase PEST, a novel modulator of the apoptotic response.12
271341722016Crystal Structure and Substrate Specificity of PTPN12.9

Citation

Dessen P

PTPN12 (protein tyrosine phosphatase non-receptor type 12)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41911/ptpn12-(protein-tyrosine-phosphatase-non-receptor-type-12)