PTPN2 (protein tyrosine phosphatase non-receptor type 2)

2003-11-01  

Identity

HGNC
PTPN2
LOCATION
18p11.21
LOCUSID
5771
ALIAS
PTN2,PTPT,TC-PTP,TCELLPTP,TCPTP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5771
MIM: 176887
HGNC: 9650
Ensembl: ENSG00000175354

Variants:

dbSNP: 5771
ClinVar: 5771
TCGA: ENSG00000175354
COSMIC: PTPN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000175354ENST00000309660P17706
ENSG00000175354ENST00000327283P17706
ENSG00000175354ENST00000327283A8K3N4
ENSG00000175354ENST00000353319P17706
ENSG00000175354ENST00000585666K7EIE9
ENSG00000175354ENST00000587703K7ENP9
ENSG00000175354ENST00000589216K7ERU1
ENSG00000175354ENST00000591115P17706
ENSG00000175354ENST00000591305K7ERU1
ENSG00000175354ENST00000591497K7EQG9
ENSG00000175354ENST00000591901K7EIY0
ENSG00000175354ENST00000592059K7ELS9
ENSG00000175354ENST00000592776K7ER87
ENSG00000175354ENST00000645191D3DUJ3
ENSG00000175354ENST00000645816A0A2R8YD79
ENSG00000175354ENST00000646492D3DUJ3

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Jak-STAT signaling pathwayKEGGko04630
Jak-STAT signaling pathwayKEGGhsa04630
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon gamma signalingREACTOMER-HSA-877300
Regulation of IFNG signalingREACTOMER-HSA-877312
Signal TransductionREACTOMER-HSA-162582
Signaling by METREACTOMER-HSA-6806834
Negative regulation of MET activityREACTOMER-HSA-6807004

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383792212024PTPN2 inhibits the proliferation of psoriatic keratinocytes by dephosphorylation of STAT3.0
390288692024Haploinsufficiency in PTPN2 leads to early-onset systemic autoimmunity from Evans syndrome to lupus.0
383792212024PTPN2 inhibits the proliferation of psoriatic keratinocytes by dephosphorylation of STAT3.0
390288692024Haploinsufficiency in PTPN2 leads to early-onset systemic autoimmunity from Evans syndrome to lupus.0
344200442022Loss of protein tyrosine phosphatase non-receptor type 2 reduces IL-4-driven alternative macrophage activation.6
348062452022Structural characterization of a pathogenic mutant of human protein tyrosine phosphatase PTPN2 (Cys216Gly) that causes very early onset autoimmune enteropathy.5
350131942022The catalytic activity of TCPTP is auto-regulated by its intrinsically disordered tail and activated by Integrin alpha-1.17
350444562022PTPN2 Regulates the Interferon Signaling and Endoplasmic Reticulum Stress Response in Pancreatic β-Cells in Autoimmune Diabetes.7
351541222022PTPN2, A Key Predictor of Prognosis for Pancreatic Adenocarcinoma, Significantly Regulates Cell Cycles, Apoptosis, and Metastasis.8
351960852022PTPN2 elicits cell autonomous and non-cell autonomous effects on antitumor immunity in triple-negative breast cancer.14
356800182022The first association study of Protein Tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2) gene polymorphisms in Malaysian patients with Crohn's disease.0
360774222022PTPN2 in the Immunity and Tumor Immunotherapy: A Concise Review.5
364971052022Stem-Cell-Derived β-Like Cells with a Functional PTPN2 Knockout Display Increased Immunogenicity.3
344200442022Loss of protein tyrosine phosphatase non-receptor type 2 reduces IL-4-driven alternative macrophage activation.6
348062452022Structural characterization of a pathogenic mutant of human protein tyrosine phosphatase PTPN2 (Cys216Gly) that causes very early onset autoimmune enteropathy.5

Citation

Dessen P

PTPN2 (protein tyrosine phosphatase non-receptor type 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41915/deep-insight-explorer/img/logo-atlas-4.svg