PTPRN (protein tyrosine phosphatase receptor type N)

2003-11-01  

Identity

HGNC
PTPRN
LOCATION
2q35
LOCUSID
5798
ALIAS
IA-2,IA-2/PTP,IA2,ICA512,R-PTP-N
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5798
MIM: 601773
HGNC: 9676
Ensembl: ENSG00000054356

Variants:

dbSNP: 5798
ClinVar: 5798
TCGA: ENSG00000054356
COSMIC: PTPRN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000054356ENST00000295718Q16849
ENSG00000054356ENST00000409251Q16849
ENSG00000054356ENST00000412847A0A1B0GX26
ENSG00000054356ENST00000423636Q16849
ENSG00000054356ENST00000440552C9JR27
ENSG00000054356ENST00000442029C9JCQ0
ENSG00000054356ENST00000443981H7C0U9
ENSG00000054356ENST00000446182C9JJL7
ENSG00000054356ENST00000451506C9J392
ENSG00000054356ENST00000606213U3KQ66

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Type I diabetes mellitusKEGGko04940
Type I diabetes mellitusKEGGhsa04940

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
hypothalamus
thyroid gland
parathyroid gland
adrenal gland
pituitary gland
nasopharynx
bronchus
lung
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
350404772022Seroreactivity Against Tyrosine Phosphatase PTPRN Links Type 2 Diabetes and Colorectal Cancer and Identifies a Potential Diagnostic and Therapeutic Target.5
352635382022Glutamic Acid Decarboxylase and Tyrosine Phosphatase-Related Islet Antigen-2 Positivity among Children and Adolescents with Diabetes in Korea.2
350404772022Seroreactivity Against Tyrosine Phosphatase PTPRN Links Type 2 Diabetes and Colorectal Cancer and Identifies a Potential Diagnostic and Therapeutic Target.5
352635382022Glutamic Acid Decarboxylase and Tyrosine Phosphatase-Related Islet Antigen-2 Positivity among Children and Adolescents with Diabetes in Korea.2
326965932021Different interaction of onset age and duration of type 1 diabetes on the dynamics of autoantibodies to insulinoma-associated antigen-2 and zinc transporter 8.5
326965932021Different interaction of onset age and duration of type 1 diabetes on the dynamics of autoantibodies to insulinoma-associated antigen-2 and zinc transporter 8.5
297424972018Prognostic Value of Phosphotyrosine Phosphatases in Hepatocellular Carcinoma.14
297424972018Prognostic Value of Phosphotyrosine Phosphatases in Hepatocellular Carcinoma.14
265641792016Influence of HLA-DR and -DQ alleles on autoantibody recognition of distinct epitopes within the juxtamembrane domain of the IA-2 autoantigen in type 1 diabetes.0
268360202016Biochemical, biophysical, and functional properties of ICA512/IA-2 RESP18 homology domain.6
278811172016Novel prokaryotic expression of thioredoxin-fused insulinoma associated protein tyrosine phosphatase 2 (IA-2), its characterization and immunodiagnostic application.5
265641792016Influence of HLA-DR and -DQ alleles on autoantibody recognition of distinct epitopes within the juxtamembrane domain of the IA-2 autoantigen in type 1 diabetes.0
268360202016Biochemical, biophysical, and functional properties of ICA512/IA-2 RESP18 homology domain.6
278811172016Novel prokaryotic expression of thioredoxin-fused insulinoma associated protein tyrosine phosphatase 2 (IA-2), its characterization and immunodiagnostic application.5
255280042015The minimal promoter region of the dense-core vesicle protein IA-2: transcriptional regulation by CREB.0

Citation

Dessen P

PTPRN (protein tyrosine phosphatase receptor type N)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41935/css/js/template.js