RAB25 (RAB25, member RAS oncogene family)

2004-02-01 Affiliation

Identity

HGNC

RAB25

LOCATION

1q22

LOCUSID

57111

ALIAS

CATX-8,RAB11C

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 57111
MIM: 612942
HGNC: 18238
Ensembl: ENSG00000132698

Variants:

dbSNP: 57111
ClinVar: 57111
TCGA: ENSG00000132698
COSMIC: RAB25

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000132698	ENST00000361084	P57735

Expression (GTEx)

100

150

200

250

300

350

400

450

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
RAB geranylgeranylation	REACTOME	R-HSA-8873719

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
38803515	2024	Loss of RAB25 Cooperates with Oncogenes in the Transformation of Human Mammary Epithelial Cells (HMECs) to Give Rise to Claudin-Low Tumors.	1
38803515	2024	Loss of RAB25 Cooperates with Oncogenes in the Transformation of Human Mammary Epithelial Cells (HMECs) to Give Rise to Claudin-Low Tumors.	1
37246119	2023	Expression of Rab25 is down-regulated in the foreskin of children with hypospadias.	0
37246119	2023	Expression of Rab25 is down-regulated in the foreskin of children with hypospadias.	0
33015770	2020	Long non-coding RNA LINC00173 serves as sponge for miR-338-3p to promote prostate cancer progression via regulating Rab25.	10
33015770	2020	Long non-coding RNA LINC00173 serves as sponge for miR-338-3p to promote prostate cancer progression via regulating Rab25.	10
30848009	2019	Rab25 promotes erlotinib resistance by activating the β1 integrin/AKT/β-catenin pathway in NSCLC.	15
31144312	2019	Loss of Rab25 promotes the development of skin squamous cell carcinoma through the dysregulation of integrin trafficking.	10
30848009	2019	Rab25 promotes erlotinib resistance by activating the β1 integrin/AKT/β-catenin pathway in NSCLC.	15
31144312	2019	Loss of Rab25 promotes the development of skin squamous cell carcinoma through the dysregulation of integrin trafficking.	10
29371698	2018	Rab25 augments cancer cell invasiveness through a β1 integrin/EGFR/VEGF-A/Snail signaling axis and expression of fascin.	31
29524309	2018	MiR-577 suppresses epithelial-mesenchymal transition and metastasis of breast cancer by targeting Rab25.	28
30445998	2018	ZEB2 stably represses RAB25 expression through epigenetic regulation by SIRT1 and DNMTs during epithelial-to-mesenchymal transition.	9
29371698	2018	Rab25 augments cancer cell invasiveness through a β1 integrin/EGFR/VEGF-A/Snail signaling axis and expression of fascin.	31
29524309	2018	MiR-577 suppresses epithelial-mesenchymal transition and metastasis of breast cancer by targeting Rab25.	28

Citation

Dessen P

RAB25 (RAB25, member RAS oncogene family)

Atlas Genet Cytogenet Oncol Haematol. 2004-02-01

Online version: http://atlasgeneticsoncology.org/gene/41970/favicon/apple-touch-icon.png