RAB4A (RAB4A, member RAS oncogene family)

2003-11-01 Affiliation

Identity

HGNC

RAB4A

LOCATION

1q42.13

LOCUSID

5867

ALIAS

HRES-1,HRES-1/RAB4,HRES1,RAB4

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5867
MIM: 179511
HGNC: 9781
Ensembl: ENSG00000168118

Variants:

dbSNP: 5867
ClinVar: 5867
TCGA: ENSG00000168118
COSMIC: RAB4A

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000168118	ENST00000366690	P20338
ENSG00000168118	ENST00000366690	A0A024R3U9
ENSG00000168118	ENST00000618010	A0A087WYT5

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Endocytosis	KEGG	ko04144
Endocytosis	KEGG	hsa04144
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Signal Transduction	REACTOME	R-HSA-162582
Vesicle-mediated transport	REACTOME	R-HSA-5653656
Membrane Trafficking	REACTOME	R-HSA-199991
Translocation of GLUT4 to the plasma membrane	REACTOME	R-HSA-1445148
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Phospholipid metabolism	REACTOME	R-HSA-1483257
PI Metabolism	REACTOME	R-HSA-1483255
Synthesis of PIPs at the plasma membrane	REACTOME	R-HSA-1660499
Signaling by MET	REACTOME	R-HSA-6806834
MET receptor recycling	REACTOME	R-HSA-8875656
TBC/RABGAPs	REACTOME	R-HSA-8854214
RAB geranylgeranylation	REACTOME	R-HSA-8873719

References

Pubmed ID	Year	Title	Citations
19201859	2009	Activation of mammalian target of rapamycin controls the loss of TCRzeta in lupus T cells through HRES-1/Rab4-regulated lysosomal degradation.	80
16926431	2006	The GTPase Rab4 interacts with Chlamydia trachomatis inclusion membrane protein CT229.	75
15689494	2005	From sorting endosomes to exocytosis: association of Rab4 and Rab11 GTPases with the Fc receptor, FcRn, during recycling.	63
15292453	2004	Elevated endosomal cholesterol levels in Niemann-Pick cells inhibit rab4 and perturb membrane recycling.	58
19369423	2009	Cargo-mediated regulation of a rapid Rab4-dependent recycling pathway.	56
11786538	2002	Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein.	53
17786215	2007	The N-Myc down regulated Gene1 (NDRG1) Is a Rab4a effector involved in vesicular recycling of E-cadherin.	45
21669283	2011	Upregulation of select rab GTPases in cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease.	40
20534812	2010	Functional cross-talk between Rab14 and Rab4 through a dual effector, RUFY1/Rabip4.	31
16935861	2006	Regulation of CD4 expression via recycling by HRES-1/RAB4 controls susceptibility to HIV infection.	29

Citation

Dessen P

RAB4A (RAB4A, member RAS oncogene family)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41999/rab4a-(rab4a-member-ras-oncogene-family)