RAB6A (RAB6A, member RAS oncogene family)

2003-11-01  

Identity

HGNC
RAB6A
LOCATION
11q13.4
LOCUSID
5870
ALIAS
RAB6
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5870
MIM: 179513
HGNC: 9786
Ensembl: ENSG00000175582

Variants:

dbSNP: 5870
ClinVar: 5870
TCGA: ENSG00000175582
COSMIC: RAB6A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000175582ENST00000310653P20340
ENSG00000175582ENST00000310653A0A024R5H8
ENSG00000175582ENST00000336083P20340
ENSG00000175582ENST00000336083A0A024R5J5
ENSG00000175582ENST00000536566F5GX61
ENSG00000175582ENST00000537446F5GX61
ENSG00000175582ENST00000540771F5H3K7
ENSG00000175582ENST00000541588P20340
ENSG00000175582ENST00000541973P20340
ENSG00000175582ENST00000545625F5GX61

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Pre-NOTCH Expression and ProcessingREACTOMER-HSA-1912422
Pre-NOTCH Processing in GolgiREACTOMER-HSA-1912420
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Retrograde transport at the Trans-Golgi-NetworkREACTOMER-HSA-6811440
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-independent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811436
Neutrophil degranulationREACTOMER-HSA-6798695
RAB GEFs exchange GTP for GDP on RABsREACTOMER-HSA-8876198
TBC/RABGAPsREACTOMER-HSA-8854214
RAB geranylgeranylationREACTOMER-HSA-8873719

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
372785692023RAB6A functions as a critical modulator of the stem-like subsets in cholangiocarcinoma.0
372785692023RAB6A functions as a critical modulator of the stem-like subsets in cholangiocarcinoma.0
330127812020Small GTPase RAB6 deficiency promotes alveolar progenitor cell renewal and attenuates PM2.5-induced lung injury and fibrosis.17
332471822020Rab6 regulates recycling and retrograde trafficking of MR1 molecules.6
330127812020Small GTPase RAB6 deficiency promotes alveolar progenitor cell renewal and attenuates PM2.5-induced lung injury and fibrosis.17
332471822020Rab6 regulates recycling and retrograde trafficking of MR1 molecules.6
284487372019Involvement of ARHGEF10, GEF for RhoA, in Rab6/Rab8-mediating membrane traffic.10
311425542019RAB6 and microtubules restrict protein secretion to focal adhesions.46
284487372019Involvement of ARHGEF10, GEF for RhoA, in Rab6/Rab8-mediating membrane traffic.10
311425542019RAB6 and microtubules restrict protein secretion to focal adhesions.46
291445622018MiR-5100 increases the cisplatin resistance of the lung cancer stem cells by inhibiting the Rab6.14
294403642018Rab6-dependent retrograde traffic of LAT controls immune synapse formation and T cell activation.24
291445622018MiR-5100 increases the cisplatin resistance of the lung cancer stem cells by inhibiting the Rab6.14
294403642018Rab6-dependent retrograde traffic of LAT controls immune synapse formation and T cell activation.24
275505192016ARHGEF10 directs the localization of Rab8 to Rab6-positive executive vesicles.14

Citation

Dessen P

RAB6A (RAB6A, member RAS oncogene family)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42004/css/case-report-explorer/js/lib/all.min.js