RAD23A (RAD23 homolog A, nucleotide excision repair protein)

2003-02-01  

Identity

HGNC
LOCATION
19p13.13
LOCUSID
ALIAS
HHR23A,HR23A
FUSION GENES

Other Information

Locus ID:

NCBI: 5886
MIM: 600061
HGNC: 9812
Ensembl: ENSG00000179262

Variants:

dbSNP: 5886
ClinVar: 5886
TCGA: ENSG00000179262
COSMIC: RAD23A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000179262ENST00000316856P54725
ENSG00000179262ENST00000586375K7ELU6
ENSG00000179262ENST00000586534P54725
ENSG00000179262ENST00000586534A0A024R7G8
ENSG00000179262ENST00000590881K7EQ16
ENSG00000179262ENST00000591499K7ELW1
ENSG00000179262ENST00000592268P54725
ENSG00000179262ENST00000593114K7ENJ0
ENSG00000179262ENST00000651137A0A494C0B4

Expression (GTEx)

0
100
200
300
400
500
600
700

Pathways

PathwaySourceExternal ID
Nucleotide excision repairKEGGko03420
Nucleotide excision repairKEGGhsa03420
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DNA RepairREACTOMER-HSA-73894
Nucleotide Excision RepairREACTOMER-HSA-5696398
Global Genome Nucleotide Excision Repair (GG-NER)REACTOMER-HSA-5696399
DNA Damage Recognition in GG-NERREACTOMER-HSA-5696394
Formation of Incision Complex in GG-NERREACTOMER-HSA-5696395
DeubiquitinationREACTOMER-HSA-5688426
Josephin domain DUBsREACTOMER-HSA-5689877

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
120793612002Solution structures of UBA domains reveal a conserved hydrophobic surface for protein-protein interactions.57
153217272004Binding of polyubiquitin chains to ubiquitin-associated (UBA) domains of HHR23A.55
129701762003Structural determinants for the binding of ubiquitin-like domains to the proteasome.46
145575492003DNA-repair protein hHR23a alters its protein structure upon binding proteasomal subunit S5a.43
146455092003Involvement of the DNA repair protein hHR23 in p53 degradation.34
170982532007Ubiquitin receptor proteins hHR23a and hPLIC2 interact.20
174086892007Defining how ubiquitin receptors hHR23a and S5a bind polyubiquitin.20
253118592014Rad23 interaction with the proteasome is regulated by phosphorylation of its ubiquitin-like (UbL) domain.13
204961652011Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk.12

Citation

Dessen P

RAD23A (RAD23 homolog A, nucleotide excision repair protein)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42027/rad23a