RALGDS (ral guanine nucleotide dissociation stimulator)

2003-02-01  

Identity

HGNC
LOCATION
9q34.13
LOCUSID
ALIAS
RGDS,RGF,RalGEF
FUSION GENES

Other Information

Locus ID:

NCBI: 5900
MIM: 601619
HGNC: 9842
Ensembl: ENSG00000160271

Variants:

dbSNP: 5900
ClinVar: 5900
TCGA: ENSG00000160271
COSMIC: RALGDS

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160271ENST00000372047Q12967
ENSG00000160271ENST00000372050Q12967
ENSG00000160271ENST00000372062Q12967
ENSG00000160271ENST00000393157Q12967
ENSG00000160271ENST00000393160Q12967
ENSG00000160271ENST00000424572Q5T7U6
ENSG00000160271ENST00000460587A0A2R8YE90
ENSG00000160271ENST00000477660A0A2R8YEX4

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Colorectal cancerKEGGko05210
Pancreatic cancerKEGGko05212
Pathways in cancerKEGGhsa05200
Colorectal cancerKEGGhsa05210
Pancreatic cancerKEGGhsa05212
Ras signaling pathwayKEGGhsa04014
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Choline metabolism in cancerKEGGhsa05231
Choline metabolism in cancerKEGGko05231
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
Signalling to ERKsREACTOMER-HSA-187687
Signalling to RASREACTOMER-HSA-167044
p38MAPK eventsREACTOMER-HSA-171007
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
177093812007Activation of the RalGEF/Ral pathway promotes prostate cancer metastasis to bone.55
121054162002Beta-arrestins regulate a Ral-GDS Ral effector pathway that mediates cytoskeletal reorganization.43
189482692008RalA functions as an indispensable signal mediator for the nutrient-sensing system.38
118403392002Regulation of choline kinase activity by Ras proteins involves Ral-GDS and PI3K.36
184177372008Guanine exchange factor RalGDS mediates exocytosis of Weibel-Palade bodies from endothelial cells.19
152083052004Activation of Ras-Ral pathway attenuates p53-independent DNA damage G2 checkpoint.8
160072232005The merlin tumor suppressor interacts with Ral guanine nucleotide dissociation stimulator and inhibits its activity.8
227384012012Role of electrostatics in differential binding of RalGDS to Rap mutations E30D and K31E investigated by vibrational spectroscopy of thiocyanate probes.4
179921252007No evidence of RALGDS mutations in cutaneous melanoma.3
198011922009Ras classical effectors: new tales from in silico complexes.3

Citation

Dessen P

RALGDS (ral guanine nucleotide dissociation stimulator)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42038/ralgds