RHO (rhodopsin)

2003-05-01 Affiliation

Identity

HGNC

RHO

LOCATION

3q22.1

LOCUSID

6010

ALIAS

CSNBAD1,OPN2,RP4

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6010
MIM: 180380
HGNC: 10012
Ensembl: ENSG00000163914

Variants:

dbSNP: 6010
ClinVar: 6010
TCGA: ENSG00000163914
COSMIC: RHO

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000163914	ENST00000296271	P08100

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Phototransduction	KEGG	ko04744
Phototransduction	KEGG	hsa04744
Organelle biogenesis and maintenance	REACTOME	R-HSA-1852241
Cilium Assembly	REACTOME	R-HSA-5617833
Cargo trafficking to the periciliary membrane	REACTOME	R-HSA-5620920
VxPx cargo-targeting to cilium	REACTOME	R-HSA-5620916
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Opsins	REACTOME	R-HSA-419771
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (i) signalling events	REACTOME	R-HSA-418594
Visual phototransduction	REACTOME	R-HSA-2187338
The canonical retinoid cycle in rods (twilight vision)	REACTOME	R-HSA-2453902
The phototransduction cascade	REACTOME	R-HSA-2514856
Activation of the phototransduction cascade	REACTOME	R-HSA-2485179
Inactivation, recovery and regulation of the phototransduction cascade	REACTOME	R-HSA-2514859

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
26200343	2015	Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser.	247
15823756	2005	Mechanisms of cell death in rhodopsin retinitis pigmentosa: implications for therapy.	144
19836958	2009	A G protein-coupled receptor at work: the rhodopsin model.	122
12091393	2002	A rhodopsin mutant linked to autosomal dominant retinitis pigmentosa is prone to aggregate and interacts with the ubiquitin proteasome system.	121
12601165	2003	Role of the conserved NPxxY(x)5,6F motif in the rhodopsin ground state and during activation.	100
11972042	2002	Naturally occurring rhodopsin mutation in the dog causes retinal dysfunction and degeneration mimicking human dominant retinitis pigmentosa.	72
28753425	2017	Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors.	72
25203160	2014	Activation of G-protein-coupled receptors correlates with the formation of a continuous internal water pathway.	59
18385078	2008	Retinal laminar architecture in human retinitis pigmentosa caused by Rhodopsin gene mutations.	56
21978933	2011	LPA receptor heterodimerizes with CD97 to amplify LPA-initiated RHO-dependent signaling and invasion in prostate cancer cells.	50

Citation

Dessen P

RHO (rhodopsin)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42106/rho-(rhodopsin)