RHOT1 (ras homolog family member T1)

2003-05-01  

Identity

HGNC
RHOT1
LOCATION
17q11.2
LOCUSID
55288
ALIAS
ARHT1,MIRO-1,MIRO1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55288
MIM: 613888
HGNC: 21168
Ensembl: ENSG00000126858

Variants:

dbSNP: 55288
ClinVar: 55288
TCGA: ENSG00000126858
COSMIC: RHOT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000126858ENST00000333942Q8IXI2
ENSG00000126858ENST00000354266H7BXZ6
ENSG00000126858ENST00000358365Q8IXI2
ENSG00000126858ENST00000394692Q8IXI2
ENSG00000126858ENST00000545287Q8IXI2
ENSG00000126858ENST00000578205J3KSR5
ENSG00000126858ENST00000580392J3QLG2
ENSG00000126858ENST00000581031Q8IXI2
ENSG00000126858ENST00000581094Q8IXI2
ENSG00000126858ENST00000581148K7EP86
ENSG00000126858ENST00000582602K7EIQ7
ENSG00000126858ENST00000583994J3KSR5
ENSG00000126858ENST00000584692J3QSG2
ENSG00000126858ENST00000584852J3KRG7
ENSG00000126858ENST00000646284A0A2R8Y4I2
ENSG00000126858ENST00000652713A0A494C061

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880
Mitophagy - animalKEGGko04137
Mitophagy - animalKEGGhsa04137

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383786442024HMGB1 promotes mitochondrial transfer between hepatocellular carcinoma cells through RHOT1 and RAC1 under hypoxia.0
383786442024HMGB1 promotes mitochondrial transfer between hepatocellular carcinoma cells through RHOT1 and RAC1 under hypoxia.0
379492202023Interaction between the mitochondrial adaptor MIRO and the motor adaptor TRAK.2
379492202023Interaction between the mitochondrial adaptor MIRO and the motor adaptor TRAK.2
351703742022Hsa_circ_0005230 is up-regulated and promotes gastric cancer cell invasion and migration via regulating the miR-1299/RHOT1 axis.7
351703742022Hsa_circ_0005230 is up-regulated and promotes gastric cancer cell invasion and migration via regulating the miR-1299/RHOT1 axis.7
329483532021The role of RHOT1 and RHOT2 genetic variation on Parkinson disease risk and onset.0
336869572021Circular RNA RHOT1 promotes progression and inhibits ferroptosis via mir-106a-5p/STAT3 axis in breast cancer.56
344069782021Circular RNA circRHOT1 contributes to pathogenesis of non-small cell lung cancer by epigenetically enhancing C-MYC expression through recruiting KAT5.9
344311322021Miro1 functions as an inhibitory regulator of MFN at elevated mitochondrial Ca(2+) levels.4
329483532021The role of RHOT1 and RHOT2 genetic variation on Parkinson disease risk and onset.0
336869572021Circular RNA RHOT1 promotes progression and inhibits ferroptosis via mir-106a-5p/STAT3 axis in breast cancer.56
344069782021Circular RNA circRHOT1 contributes to pathogenesis of non-small cell lung cancer by epigenetically enhancing C-MYC expression through recruiting KAT5.9
344311322021Miro1 functions as an inhibitory regulator of MFN at elevated mitochondrial Ca(2+) levels.4
320563172020Miro: A molecular switch at the center of mitochondrial regulation.24

Citation

Dessen P

RHOT1 (ras homolog family member T1)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42114/teaching-explorer/gene-fusions-explorer/js/lib/jquery-3.5.1.min.js