RINT1 (RAD50 interactor 1)

2003-02-01  

Identity

HGNC
LOCATION
7q22.3
LOCUSID
ALIAS
ILFS3,RINT-1
FUSION GENES

Other Information

Locus ID:

NCBI: 60561
MIM: 610089
HGNC: 21876
Ensembl: ENSG00000135249

Variants:

dbSNP: 60561
ClinVar: 60561
TCGA: ENSG00000135249
COSMIC: RINT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135249ENST00000257700Q6NUQ1
ENSG00000135249ENST00000467392F8WC46
ENSG00000135249ENST00000482041F8WAZ2
ENSG00000135249ENST00000493041C9J5S3
ENSG00000135249ENST00000497979F8WDC5

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-dependent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811434

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
176995962007Rab6 regulates both ZW10/RINT-1 and conserved oligomeric Golgi complex-dependent Golgi trafficking and homeostasis.43
165716792006RINT-1 regulates the localization and entry of ZW10 to the syntaxin 18 complex.34
193694182009Identification of the neuroblastoma-amplified gene product as a component of the syntaxin 18 complex implicated in Golgi-to-endoplasmic reticulum retrograde transport.32
174705492007RINT-1 serves as a tumor suppressor and maintains Golgi dynamics and centrosome integrity for cell survival.18
250505582014Rare mutations in RINT1 predispose carriers to breast and Lynch syndrome-spectrum cancers.16
238851182013A new role for RINT-1 in SNARE complex assembly at the trans-Golgi network in coordination with the COG complex.12
275442262016Reevaluation of RINT1 as a breast cancer predisposition gene.7
230741962012Integrative functional genomics identifies RINT1 as a novel GBM oncogene.5
253046162015Expression of RINT1 predicts seizure occurrence and outcomes in patients with low-grade gliomas.3
280313582017Association of Human Papillomavirus 16 E2 with Rad50-Interacting Protein 1 Enhances Viral DNA Replication.3

Citation

Dessen P

RINT1 (RAD50 interactor 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42118/rint1