RIPK1 (receptor interacting serine/threonine kinase 1)

2003-08-01  

Identity

HGNC
LOCATION
6p25.2
LOCUSID
ALIAS
AIEFL,IMD57,RIP,RIP-1,RIP1
FUSION GENES

Other Information

Locus ID:

NCBI: 8737
MIM: 603453
HGNC: 10019
Ensembl: ENSG00000137275

Variants:

dbSNP: 8737
ClinVar: 8737
TCGA: ENSG00000137275
COSMIC: RIPK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137275ENST00000259808Q13546
ENSG00000137275ENST00000259808A0A024QZU0
ENSG00000137275ENST00000380409Q13546
ENSG00000137275ENST00000380409A0A024QZU0

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
ApoptosisKEGGko04210
Toll-like receptor signaling pathwayKEGGko04620
ApoptosisKEGGhsa04210
Toll-like receptor signaling pathwayKEGGhsa04620
RIG-I-like receptor signaling pathwayKEGGko04622
RIG-I-like receptor signaling pathwayKEGGhsa04622
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Cytosolic DNA-sensing pathwayKEGGko04623
Cytosolic DNA-sensing pathwayKEGGhsa04623
Hepatitis CKEGGko05160
Hepatitis CKEGGhsa05160
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
NF-kappa B signaling pathwayKEGGhsa04064
NF-kappa B signaling pathwayKEGGko04064
TNF signaling pathwayKEGGhsa04668
TNF signaling pathwayKEGGko04668
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Toll-Like Receptors CascadesREACTOMER-HSA-168898
Toll Like Receptor 3 (TLR3) CascadeREACTOMER-HSA-168164
MyD88-independent TLR3/TLR4 cascadeREACTOMER-HSA-166166
TRIF-mediated TLR3/TLR4 signalingREACTOMER-HSA-937061
IKK complex recruitment mediated by RIP1REACTOMER-HSA-937041
TRIF-mediated programmed cell deathREACTOMER-HSA-2562578
Toll Like Receptor 4 (TLR4) CascadeREACTOMER-HSA-166016
Activated TLR4 signallingREACTOMER-HSA-166054
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysREACTOMER-HSA-168928
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10REACTOMER-HSA-933543
Cytosolic sensors of pathogen-associated DNAREACTOMER-HSA-1834949
ZBP1(DAI) mediated induction of type I IFNsREACTOMER-HSA-1606322
RIP-mediated NFkB activation via ZBP1REACTOMER-HSA-1810476
Signal TransductionREACTOMER-HSA-162582
Death Receptor SignallingREACTOMER-HSA-73887
TNF signalingREACTOMER-HSA-75893
TNFR1-induced proapoptotic signalingREACTOMER-HSA-5357786
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Caspase activation via extrinsic apoptotic signalling pathwayREACTOMER-HSA-5357769
Ligand-dependent caspase activationREACTOMER-HSA-140534
Dimerization of procaspase-8REACTOMER-HSA-69416
Regulation by c-FLIPREACTOMER-HSA-3371378
Regulated NecrosisREACTOMER-HSA-5218859
RIPK1-mediated regulated necrosisREACTOMER-HSA-5213460
Regulation of necroptotic cell deathREACTOMER-HSA-5675482
CASP8 activity is inhibitedREACTOMER-HSA-5218900
TNFR1-induced NFkappaB signaling pathwayREACTOMER-HSA-5357956
Regulation of TNFR1 signalingREACTOMER-HSA-5357905
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880
Ovarian tumor domain proteasesREACTOMER-HSA-5689896

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
185708722008cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination.383
166033982006Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO.358
228178962012The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis.335
179966482007Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis.249
186217372008c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation.200
203542262010The role of the kinases RIP1 and RIP3 in TNF-induced necrosis.180
173018402007RIP1, a kinase on the crossroads of a cell's decision to live or die.167
145322862003A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses.153
260861432015The diverse role of RIP kinases in necroptosis and inflammation.136
211131352010c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling.125

Citation

Dessen P

RIPK1 (receptor interacting serine/threonine kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/42119/ripk1