PCGF2 (polycomb group ring finger 2)

2003-02-01  

Identity

HGNC
LOCATION
17q12
LOCUSID
ALIAS
MEL-18,RNF110,TPFS,ZNF144
FUSION GENES

Other Information

Locus ID:

NCBI: 7703
MIM: 600346
HGNC: 12929
Ensembl: ENSG00000277258

Variants:

dbSNP: 7703
ClinVar: 7703
TCGA: ENSG00000277258
COSMIC: PCGF2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000277258ENST00000610747A0A087X0Y6
ENSG00000277258ENST00000611883P35227
ENSG00000277258ENST00000611883A0A024R1V6
ENSG00000277258ENST00000616129J3KT13
ENSG00000277258ENST00000616199P35227
ENSG00000277258ENST00000616199A0A024R1V6
ENSG00000277258ENST00000618506A0A087X259
ENSG00000277258ENST00000618941J3KT13
ENSG00000277258ENST00000620225P35227
ENSG00000277258ENST00000620225A0A024R1V6

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Signaling pathways regulating pluripotency of stem cellsKEGGhsa04550
Signaling pathways regulating pluripotency of stem cellsKEGGko04550
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
SUMO E3 ligases SUMOylate target proteinsREACTOMER-HSA-3108232
SUMOylation of DNA damage response and repair proteinsREACTOMER-HSA-3108214
Developmental BiologyREACTOMER-HSA-1266738
SUMOylation of RNA binding proteinsREACTOMER-HSA-4570464
Activation of HOX genes during differentiationREACTOMER-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesisREACTOMER-HSA-5617472

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
171513612007Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteins.58
175455842007Mel-18 acts as a tumor suppressor by repressing Bmi-1 expression and down-regulating Akt activity in breast cancer cells.55
179367082007A phosphorylated form of Mel-18 targets the Ring1B histone H2A ubiquitin ligase to chromatin.47
174524562007Contribution of polycomb homologues Bmi-1 and Mel-18 to medulloblastoma pathogenesis.42
234747522014Loss of the polycomb protein Mel-18 enhances the epithelial-mesenchymal transition by ZEB1 and ZEB2 expression through the downregulation of miR-205 in breast cancer.39
115204622001Regulation of Th2 cell differentiation by mel-18, a mammalian polycomb group gene.32
201705412010BMI1 and Mel-18 oppositely regulate carcinogenesis and progression of gastric cancer.29
171458102006Implication of polycomb members Bmi-1, Mel-18, and Hpc-2 in the regulation of p16INK4a, p14ARF, h-TERT, and c-Myc expression in primary breast carcinomas.28
216028902011Loss of Mel-18 induces tumor angiogenesis through enhancing the activity and expression of HIF-1α mediated by the PTEN/PI3K/Akt pathway.22
176729182007Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.17

Citation

Dessen P

PCGF2 (polycomb group ring finger 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42125/pcgf2-(polycomb-group-ring-finger-2)