RORB (RAR related orphan receptor B)

2003-05-01  

Identity

HGNC
RORB
LOCATION
9q21.13
LOCUSID
6096
ALIAS
EIG15,NR1F2,ROR-BETA,RZR-BETA,RZRB,bA133M9.1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6096
MIM: 601972
HGNC: 10259
Ensembl: ENSG00000198963

Variants:

dbSNP: 6096
ClinVar: 6096
TCGA: ENSG00000198963
COSMIC: RORB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198963ENST00000376896Q92753
ENSG00000198963ENST00000376896Q58EY0
ENSG00000198963ENST00000396204Q92753
ENSG00000198963ENST00000396204A0A1L4FMK7

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Circadian rhythmKEGGko04710
Circadian rhythmKEGGhsa04710
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Nuclear Receptor transcription pathwayREACTOMER-HSA-383280

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
198399952009Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia.49
202019262010Human variation in alcohol response is influenced by variation in neuronal signaling genes.45
199095002009Evidence for genetic association of RORB with bipolar disorder.39
257898102015Investigation of associations between NR1D1, RORA and RORB genes and bipolar disorder.12
118497522002Rhythmic expression of ROR beta mRNA in the mice suprachiasmatic nucleus.10
273529682016Loss of function of the retinoid-related nuclear receptor (RORB) gene and epilepsy.7
241257212013Identification of Rorβ targets in cultured osteoblasts and in human bone.6
258161512015Retinoic acid-related orphan receptor RORβ, circadian rhythm abnormalities and tumorigenesis (Review).5
281372782017Up-regulated NRIP2 in colorectal cancer initiating cells modulates the Wnt pathway by targeting RORβ.4

Citation

Dessen P

RORB (RAR related orphan receptor B)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42143/rorb