RPS6KB1 (ribosomal protein S6 kinase B1)

2003-11-01  

Identity

HGNC
LOCATION
17q23.1
LOCUSID
ALIAS
PS6K,S6K,S6K-beta-1,S6K1,STK14A,p70
FUSION GENES

Other Information

Locus ID:

NCBI: 6198
MIM: 608938
HGNC: 10436
Ensembl: ENSG00000108443

Variants:

dbSNP: 6198
ClinVar: 6198
TCGA: ENSG00000108443
COSMIC: RPS6KB1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108443ENST00000225577P23443
ENSG00000108443ENST00000393021P23443
ENSG00000108443ENST00000406116P23443
ENSG00000108443ENST00000443572P23443
ENSG00000108443ENST00000472940K7ER06
ENSG00000108443ENST00000489824K7EMM2
ENSG00000108443ENST00000592726K7EIM2

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
ErbB signaling pathwayKEGGko04012
Autophagy - animalKEGGko04140
mTOR signaling pathwayKEGGko04150
TGF-beta signaling pathwayKEGGko04350
Insulin signaling pathwayKEGGko04910
Acute myeloid leukemiaKEGGko05221
ErbB signaling pathwayKEGGhsa04012
Autophagy - animalKEGGhsa04140
mTOR signaling pathwayKEGGhsa04150
TGF-beta signaling pathwayKEGGhsa04350
Insulin signaling pathwayKEGGhsa04910
Acute myeloid leukemiaKEGGhsa05221
Fc gamma R-mediated phagocytosisKEGGko04666
Fc gamma R-mediated phagocytosisKEGGhsa04666
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
HIF-1 signaling pathwayKEGGhsa04066
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
AMPK signaling pathwayKEGGhsa04152
AMPK signaling pathwayKEGGko04152
Choline metabolism in cancerKEGGhsa05231
Choline metabolism in cancerKEGGko05231
Signal TransductionREACTOMER-HSA-162582
Signaling by Insulin receptorREACTOMER-HSA-74752
Insulin receptor signalling cascadeREACTOMER-HSA-74751
IRS-mediated signallingREACTOMER-HSA-112399
PI3K CascadeREACTOMER-HSA-109704
PKB-mediated eventsREACTOMER-HSA-109703
mTOR signallingREACTOMER-HSA-165159
mTORC1-mediated signallingREACTOMER-HSA-166208
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)REACTOMER-HSA-2404192
IGF1R signaling cascadeREACTOMER-HSA-2428924
IRS-related events triggered by IGF1RREACTOMER-HSA-2428928
Insulin resistanceKEGGhsa04931
Longevity regulating pathwayKEGGhsa04211
Longevity regulating pathway - multiple speciesKEGGko04213
Longevity regulating pathway - multiple speciesKEGGhsa04213
EGFR tyrosine kinase inhibitor resistanceKEGGko01521
Endocrine resistanceKEGGko01522
EGFR tyrosine kinase inhibitor resistanceKEGGhsa01521
Endocrine resistanceKEGGhsa01522
Breast cancerKEGGko05224
Breast cancerKEGGhsa05224
Apelin signaling pathwayKEGGhsa04371

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
162860062005mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events.389
170531472006S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth.259
158998892005Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase.207
155339962004Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis.194
160490092005hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase.178
199959152010mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling.170
224399342012The crosstalk of mTOR/S6K1 and Hedgehog pathways.143
170524532006S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt.128
157230492005Atrophy of S6K1(-/-) skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control.124
184232012008SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs.124

Citation

Dessen P

RPS6KB1 (ribosomal protein S6 kinase B1)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/42168/rps6kb1