RRAS (RAS related)

2003-02-01 Affiliation

Identity

HGNC

RRAS

LOCATION

19q13.33

LOCUSID

6237

ALIAS

R-Ras

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6237
MIM: 165090
HGNC: 10447
Ensembl: ENSG00000126458

Variants:

dbSNP: 6237
ClinVar: 6237
TCGA: ENSG00000126458
COSMIC: RRAS

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000126458	ENST00000246792	P10301
ENSG00000126458	ENST00000246792	A0A024QZF2

Expression (GTEx)

100

200

300

400

500

600

700

800

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
MAPK signaling pathway	KEGG	ko04010
Autophagy - animal	KEGG	ko04140
Axon guidance	KEGG	ko04360
Regulation of actin cytoskeleton	KEGG	ko04810
MAPK signaling pathway	KEGG	hsa04010
Autophagy - animal	KEGG	hsa04140
Axon guidance	KEGG	hsa04360
Regulation of actin cytoskeleton	KEGG	hsa04810
HTLV-I infection	KEGG	ko05166
HTLV-I infection	KEGG	hsa05166
Proteoglycans in cancer	KEGG	hsa05205
Proteoglycans in cancer	KEGG	ko05205
Ras signaling pathway	KEGG	hsa04014
Rap1 signaling pathway	KEGG	hsa04015
Rap1 signaling pathway	KEGG	ko04015
cAMP signaling pathway	KEGG	hsa04024
cAMP signaling pathway	KEGG	ko04024
Neuronal System	REACTOME	R-HSA-112316
Transmission across Chemical Synapses	REACTOME	R-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	REACTOME	R-HSA-112314
Activation of NMDA receptor upon glutamate binding and postsynaptic events	REACTOME	R-HSA-442755
Post NMDA receptor activation events	REACTOME	R-HSA-438064
CREB phosphorylation through the activation of Ras	REACTOME	R-HSA-442742
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
Semaphorin interactions	REACTOME	R-HSA-373755
Sema4D in semaphorin signaling	REACTOME	R-HSA-400685
Sema4D mediated inhibition of cell attachment and migration	REACTOME	R-HSA-416550
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	REACTOME	R-HSA-399955
Phospholipase D signaling pathway	KEGG	ko04072
Phospholipase D signaling pathway	KEGG	hsa04072
Apelin signaling pathway	KEGG	hsa04371
Mitophagy - animal	KEGG	ko04137
Mitophagy - animal	KEGG	hsa04137

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association
PA24928	ARAF	Gene	Pathway	associated
PA25408	BRAF	Gene	Pathway	associated
PA30592	MAP3K1	Gene	Pathway	associated
PA34183	RAF1	Gene	Pathway	associated
PA7360	EGFR	Gene	Pathway	associated

References

Pubmed ID	Year	Title	Citations
15297673	2004	The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras.	139
20385769	2010	Semaphorin 3E initiates antiangiogenic signaling through plexin D1 by regulating Arf6 and R-Ras.	63
22897853	2012	Small GTPase R-Ras regulates integrity and functionality of tumor blood vessels.	41
15525681	2005	R-Ras controls membrane protrusion and cell migration through the spatial regulation of Rac and Rho.	40
19843518	2009	Structure and function of the intracellular region of the plexin-b1 transmembrane receptor.	37
24705357	2014	Activating mutations in RRAS underlie a phenotype within the RASopathy spectrum and contribute to leukaemogenesis.	33
17664272	2007	Mammalian NOTCH-1 activates beta1 integrins via the small GTPase R-Ras.	31
16754664	2006	Cyclic AMP-dependent and Epac-mediated activation of R-Ras by G protein-coupled receptors leads to phospholipase D stimulation.	30
20585650	2010	R-Ras regulates migration through an interaction with filamin A in melanoma cells.	29
12529399	2003	R-Ras promotes focal adhesion formation through focal adhesion kinase and p130(Cas) by a novel mechanism that differs from integrins.	26

Citation

Dessen P

RRAS (RAS related)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42172/rras-(ras-related)