CLIP1 (CAP-Gly domain containing linker protein 1)

2003-02-01  

Identity

HGNC
CLIP1
LOCATION
12q24.31
LOCUSID
6249
ALIAS
CLIP,CLIP-170,CLIP170,CYLN1,RSN
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6249
MIM: 179838
HGNC: 10461
Ensembl: ENSG00000130779

Variants:

dbSNP: 6249
ClinVar: 6249
TCGA: ENSG00000130779
COSMIC: CLIP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130779ENST00000302528P30622
ENSG00000130779ENST00000302528A0A024RBR1
ENSG00000130779ENST00000358808P30622
ENSG00000130779ENST00000358808A0A024RBR1
ENSG00000130779ENST00000361654J3KP58
ENSG00000130779ENST00000535290F5H270
ENSG00000130779ENST00000536634A0A3B3IS27
ENSG00000130779ENST00000537123A0A3B3ISJ8
ENSG00000130779ENST00000537178P30622
ENSG00000130779ENST00000539080F5H367
ENSG00000130779ENST00000540304F5H6A0
ENSG00000130779ENST00000540338P30622
ENSG00000130779ENST00000541108F5H1T5
ENSG00000130779ENST00000545889F5H0N7
ENSG00000130779ENST00000620786P30622
ENSG00000130779ENST00000648993A0A3B3ITA2

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
mTOR signaling pathwayKEGGko04150
mTOR signaling pathwayKEGGhsa04150
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases activate IQGAPsREACTOMER-HSA-5626467
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
387059332024CLIP170 inhibits the metastasis and EMT of papillary thyroid cancer through the TGF-β pathway.0
387059332024CLIP170 inhibits the metastasis and EMT of papillary thyroid cancer through the TGF-β pathway.0
373658892023Restin protein expression in non-small cell lung cancer.1
373658892023Restin protein expression in non-small cell lung cancer.1
333720352021SOCS3-microtubule interaction via CLIP-170 and CLASP2 is critical for modulation of endothelial inflammation and lung injury.8
346729712021CLIP-170S is a microtubule +TIP variant that confers resistance to taxanes by impairing drug-target engagement.4
348196632021The CLIP1-LTK fusion is an oncogenic driver in non-small-cell lung cancer.29
333720352021SOCS3-microtubule interaction via CLIP-170 and CLASP2 is critical for modulation of endothelial inflammation and lung injury.8
346729712021CLIP-170S is a microtubule +TIP variant that confers resistance to taxanes by impairing drug-target engagement.4
348196632021The CLIP1-LTK fusion is an oncogenic driver in non-small-cell lung cancer.29
324911512020Stress-induced phosphorylation of CLIP-170 by JNK promotes microtubule rescue.6
324911512020Stress-induced phosphorylation of CLIP-170 by JNK promotes microtubule rescue.6
304553562019Mapping multivalency in the CLIP-170-EB1 microtubule plus-end complex.12
305370202019CLIP-170 spatially modulates receptor tyrosine kinase recycling to coordinate cell migration.5
306552862019Long noncoding RNA ANRIL regulates endothelial cell activities associated with coronary artery disease by up-regulating CLIP1, EZR, and LYVE1 genes.31

Citation

Dessen P

CLIP1 (CAP-Gly domain containing linker protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42178/deep-insight-explorer/js/web-card-gene.js