SEC31A (SEC31 homolog A, COPII coat complex component)

2003-05-01  

Identity

HGNC
LOCATION
4q21.22
LOCUSID
ALIAS
ABP125,ABP130,HSPC275,HSPC334,NEDSOSB,SEC31L1
FUSION GENES

Other Information

Locus ID:

NCBI: 22872
MIM: 610257
HGNC: 17052
Ensembl: ENSG00000138674

Variants:

dbSNP: 22872
ClinVar: 22872
TCGA: ENSG00000138674
COSMIC: SEC31A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138674ENST00000264405H7BXG7
ENSG00000138674ENST00000311785O94979
ENSG00000138674ENST00000348405O94979
ENSG00000138674ENST00000348405A0A024RDH6
ENSG00000138674ENST00000355196O94979
ENSG00000138674ENST00000355196A0A024RDD3
ENSG00000138674ENST00000395310O94979
ENSG00000138674ENST00000395310A0A024RDD3
ENSG00000138674ENST00000443462O94979
ENSG00000138674ENST00000448323O94979
ENSG00000138674ENST00000448323A0A024RDD3
ENSG00000138674ENST00000500777O94979
ENSG00000138674ENST00000503058H0Y9T9
ENSG00000138674ENST00000503210D6RBT0
ENSG00000138674ENST00000503937H0Y8W8
ENSG00000138674ENST00000505434D6REA9
ENSG00000138674ENST00000505472D6REX3
ENSG00000138674ENST00000505984O94979
ENSG00000138674ENST00000506495D6REC0
ENSG00000138674ENST00000507051U3KQR3
ENSG00000138674ENST00000507340D6RAB3
ENSG00000138674ENST00000507676U3KQC9
ENSG00000138674ENST00000507816D6RHE8
ENSG00000138674ENST00000507828H0YAB3
ENSG00000138674ENST00000508479D6RHZ5
ENSG00000138674ENST00000508502O94979
ENSG00000138674ENST00000509142O94979
ENSG00000138674ENST00000510167H0Y8V7
ENSG00000138674ENST00000511338H0Y9V3
ENSG00000138674ENST00000512664H0Y9K1
ENSG00000138674ENST00000513323D6RE64
ENSG00000138674ENST00000513858O94979
ENSG00000138674ENST00000514326D6RCQ9
ENSG00000138674ENST00000515062H0YAF5

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
COPII complexKEGGhsa_M00404
COPII complexKEGGM00404
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
COPII (Coat Protein 2) Mediated Vesicle TransportREACTOMER-HSA-204005
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
IRE1alpha activates chaperonesREACTOMER-HSA-381070
XBP1(S) activates chaperone genesREACTOMER-HSA-381038
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen Presentation: Folding, assembly and peptide loading of class I MHCREACTOMER-HSA-983170
MHC class II antigen presentationREACTOMER-HSA-2132295
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
164079552006Structure of the Sec13/31 COPII coat cage.117
179811332007Insights into COPII coat nucleation from the structure of Sec23.Sar1 complexed with the active fragment of Sec31.100
187138352008Efficient coupling of Sec23-Sec24 to Sec13-Sec31 drives COPII-dependent collagen secretion and is essential for normal craniofacial development.69
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
169570522006The Ca2+-binding protein ALG-2 is recruited to endoplasmic reticulum exit sites by Sec31A and stabilizes the localization of Sec31A.36
213251692011JAK2 rearrangements, including the novel SEC31A-JAK2 fusion, are recurrent in classical Hodgkin lymphoma.36
161610412006Fusion of the SEC31L1 and ALK genes in an inflammatory myofibroblastic tumor.33
171961692007ALG-2 directly binds Sec31A and localizes at endoplasmic reticulum exit sites in a Ca2+-dependent manner.30
233498702013CK2 phosphorylates Sec31 and regulates ER-To-Golgi trafficking.24
250062452014Apoptosis-linked gene-2 (ALG-2)/Sec31 interactions regulate endoplasmic reticulum (ER)-to-Golgi transport: a potential effector pathway for luminal calcium.16

Citation

Dessen P

SEC31A (SEC31 homolog A, COPII coat complex component)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42237/sec31a