SELL (selectin L)

2003-08-01  

Identity

HGNC
SELL
LOCATION
1q24.2
LOCUSID
6402
ALIAS
CD62L,LAM1,LECAM1,LEU8,LNHR,LSEL,LYAM1,PLNHR,TQ1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6402
MIM: 153240
HGNC: 10720
Ensembl: ENSG00000188404

Variants:

dbSNP: 6402
ClinVar: 6402
TCGA: ENSG00000188404
COSMIC: SELL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000188404ENST00000236147P14151
ENSG00000188404ENST00000497295A0A494C0S7
ENSG00000188404ENST00000650983P14151

Expression (GTEx)

0
500
1000
1500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Cell adhesion molecules (CAMs)KEGGhsa04514
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933
Innate Immune SystemREACTOMER-HSA-168249
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
368287462023Sex-specific association of SELL gene polymorphisms with pattern hair loss in the Thai population: A candidate gene association study and in silico functional characterization.0
380604512023CD62L expression marks a functionally distinct subset of memory B cells.0
380658592023Intercellular adhesion molecule 1 and selectin l play crucial roles in ulcerative colitis.0
368287462023Sex-specific association of SELL gene polymorphisms with pattern hair loss in the Thai population: A candidate gene association study and in silico functional characterization.0
380604512023CD62L expression marks a functionally distinct subset of memory B cells.0
380658592023Intercellular adhesion molecule 1 and selectin l play crucial roles in ulcerative colitis.0
354585482022Intermediate Monocytes with PD-L1 and CD62L Expression as a Possible Player in Active SARS-CoV-2 Infection.9
357022582022The LINC00261/MiR105-5p/SELL axis is involved in dysfunction of B cell and is associated with overall survival in hepatocellular carcinoma.3
354585482022Intermediate Monocytes with PD-L1 and CD62L Expression as a Possible Player in Active SARS-CoV-2 Infection.9
357022582022The LINC00261/MiR105-5p/SELL axis is involved in dysfunction of B cell and is associated with overall survival in hepatocellular carcinoma.3
334082472021L-selectin regulates human neutrophil transendothelial migration.18
334820192021An increase in CD62L(dim) neutrophils precedes the development of pulmonary embolisms in COVID-19 patients.6
335371752021Tumors exploit CXCR4(hi)CD62L(lo) aged neutrophils to facilitate metastatic spread.23
337286412021Circulating ILC precursors expressing CD62L exhibit a type 2 signature distinctly decreased in psoriatic patients.5
347980652021CD62L expression level determines the cell fate of myeloid progenitors.5

Citation

Dessen P

SELL (selectin L)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/42249/cancer-prone-explorer/js/lib/css/template-card.css