SFRP1 (secreted frizzled related protein 1)

2003-02-01  

Identity

HGNC
SFRP1
LOCATION
8p11.21
LOCUSID
6422
ALIAS
FRP,FRP-1,FRP1,FrzA,SARP2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6422
MIM: 604156
HGNC: 10776
Ensembl: ENSG00000104332

Variants:

dbSNP: 6422
ClinVar: 6422
TCGA: ENSG00000104332
COSMIC: SFRP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104332ENST00000220772Q8N474
ENSG00000104332ENST00000379845Q6ZSL4

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Wnt signaling pathwayKEGGko04310
Wnt signaling pathwayKEGGhsa04310
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Negative regulation of TCF-dependent signaling by WNT ligand antagonistsREACTOMER-HSA-3772470

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
208234172011Medulloblastoma comprises four distinct molecular variants.407
176998512007Secreted frizzled-related protein 1 loss contributes to tumor phenotype of clear cell renal cell carcinoma.125
164499752006Aberrant methylation of the Wnt antagonist SFRP1 in breast cancer is associated with unfavourable prognosis.93
182746692008Increased expression of the WNT antagonist sFRP-1 in glaucoma elevates intraocular pressure.69
194734962009WNT signaling enhances breast cancer cell motility and blockade of the WNT pathway by sFRP1 suppresses MDA-MB-231 xenograft growth.68
160072002005Transcriptional silencing of secreted frizzled related protein 1 (SFRP 1) by promoter hypermethylation in non-small-cell lung cancer.60
174854412007c-Myc transforms human mammary epithelial cells through repression of the Wnt inhibitors DKK1 and SFRP1.57
162880332005Identification of SFRP1 as a candidate mediator of stromal-to-epithelial signaling in prostate cancer.56
161490512005The Wnt antagonist secreted frizzled-related protein-1 controls osteoblast and osteocyte apoptosis.54
166090232006Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection.53

Citation

Dessen P

SFRP1 (secreted frizzled related protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42276/sfrp1