SHPRH (SNF2 histone linker PHD RING helicase)

2003-12-01  

Identity

HGNC
LOCATION
6q24.3
LOCUSID
ALIAS
bA545I5.2
FUSION GENES

Other Information

Locus ID:

NCBI: 257218
MIM: 608048
HGNC: 19336
Ensembl: ENSG00000146414

Variants:

dbSNP: 257218
ClinVar: 257218
TCGA: ENSG00000146414
COSMIC: SHPRH

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000146414ENST00000275233Q149N8
ENSG00000146414ENST00000367503K4DI94
ENSG00000146414ENST00000367505Q149N8
ENSG00000146414ENST00000417762Q5JT88
ENSG00000146414ENST00000433355H7C2W2
ENSG00000146414ENST00000438092Q149N8
ENSG00000146414ENST00000519632Q149N8
ENSG00000146414ENST00000521977H0YBI0
ENSG00000146414ENST00000629427A0A0D9SFM0

Expression (GTEx)

0
1
2
3
4
5
6
7

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
187191062008Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks.109
171080832006Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen.94
213968732011SHPRH and HLTF act in a damage-specific manner to coordinate different forms of postreplication repair and prevent mutagenesis.79
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
284005112017SHPRH regulates rRNA transcription by recognizing the histone code in an mTOR-dependent manner.10
128372662003Cloning and characterization of a novel gene, SHPRH, encoding a conserved putative protein with SNF2/helicase and PHD-finger domains from the 6q24 region.0
171302892006Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination.0
291393352018SHPRH as a new player in ribosomal RNA transcription and its potential role in homeostasis of ribosomal DNA repeats.0
293438482018A novel protein encoded by the circular form of the SHPRH gene suppresses glioma tumorigenesis.0
311370162019Circular RNA hsa_circ_0001649 inhibits hepatocellular carcinoma progression via multiple miRNAs sponge.0

Citation

Dessen P

SHPRH (SNF2 histone linker PHD RING helicase)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/42294/shprh-(snf2-histone-linker-phd-ring-helicase)