SLK (STE20 like kinase)

2004-04-01  

Identity

HGNC
SLK
LOCATION
10q24.33
LOCUSID
9748
ALIAS
LOSK,STK2,bA16H23.1,se20-9
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9748
MIM: 616563
HGNC: 11088
Ensembl: ENSG00000065613

Variants:

dbSNP: 9748
ClinVar: 9748
TCGA: ENSG00000065613
COSMIC: SLK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000065613ENST00000335753Q9H2G2
ENSG00000065613ENST00000369755Q9H2G2

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Oocyte meiosisKEGGko04114
Oocyte meiosisKEGGhsa04114

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
319136592020Ste20-like Kinase-mediated Control of Actin Polymerization Is a New Mechanism for Thin Filament-associated Regulation of Airway Smooth Muscle Contraction.13
319136592020Ste20-like Kinase-mediated Control of Actin Polymerization Is a New Mechanism for Thin Filament-associated Regulation of Airway Smooth Muscle Contraction.13
295345782018Ste20-like kinase is upregulated in glioma and induces glioma invasion.2
295345782018Ste20-like kinase is upregulated in glioma and induces glioma invasion.2
260947692015Identification of Tpr and α-actinin-4 as two novel SLK-interacting proteins.3
260947692015Identification of Tpr and α-actinin-4 as two novel SLK-interacting proteins.3
249587722014SLK-dependent activation of ERMs controls LGN-NuMA localization and spindle orientation.44
249587722014SLK-dependent activation of ERMs controls LGN-NuMA localization and spindle orientation.44
239853222013Ste20-like protein kinase SLK (LOSK) regulates microtubule organization by targeting dynactin to the centrosome.11
239853222013Ste20-like protein kinase SLK (LOSK) regulates microtubule organization by targeting dynactin to the centrosome.11
232093042012Local phosphocycling mediated by LOK/SLK restricts ezrin function to the apical aspect of epithelial cells.48
232093042012Local phosphocycling mediated by LOK/SLK restricts ezrin function to the apical aspect of epithelial cells.48
195259802009The Ste20-like kinase SLK is required for ErbB2-driven breast cancer cell motility.22
195259802009The Ste20-like kinase SLK is required for ErbB2-driven breast cancer cell motility.22
182875412008Ste20-related protein kinase LOSK (SLK) controls microtubule radial array in interphase.13

Citation

Dessen P

SLK (STE20 like kinase)

Atlas Genet Cytogenet Oncol Haematol. 2004-04-01

Online version: http://atlasgeneticsoncology.org/gene/42329/haematological-explorer/img/js/lib/zoomerang.js