SMURF2 (SMAD specific E3 ubiquitin protein ligase 2)

2004-02-01  

Identity

HGNC
LOCATION
17q23.3
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 64750
MIM: 605532
HGNC: 16809
Ensembl: ENSG00000108854

Variants:

dbSNP: 64750
ClinVar: 64750
TCGA: ENSG00000108854
COSMIC: SMURF2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108854ENST00000262435Q9HAU4
ENSG00000108854ENST00000578386J3QRY2
ENSG00000108854ENST00000582081J3QLG1
ENSG00000108854ENST00000585301J3QQM4

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Hedgehog signaling pathwayKEGGko04340
TGF-beta signaling pathwayKEGGko04350
Ubiquitin mediated proteolysisKEGGhsa04120
Hedgehog signaling pathwayKEGGhsa04340
TGF-beta signaling pathwayKEGGhsa04350
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
Signal TransductionREACTOMER-HSA-162582
Signaling by BMPREACTOMER-HSA-201451
Signaling by TGF-beta Receptor ComplexREACTOMER-HSA-170834
TGF-beta receptor signaling activates SMADsREACTOMER-HSA-2173789
Downregulation of TGF-beta receptor signalingREACTOMER-HSA-2173788
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerREACTOMER-HSA-2173793
Downregulation of SMAD2/3:SMAD4 transcriptional activityREACTOMER-HSA-2173795
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Degradation of AXINREACTOMER-HSA-4641257
Beta-catenin independent WNT signalingREACTOMER-HSA-3858494
PCP/CE pathwayREACTOMER-HSA-4086400
Asymmetric localization of PCP proteinsREACTOMER-HSA-4608870
Signaling by HedgehogREACTOMER-HSA-5358351
Hedgehog 'on' stateREACTOMER-HSA-5632684
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
177195432007Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain.108
160611772005Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain.98
195570012009REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A-DDB1 ubiquitin ligase.62
222315582012A tumor suppressor function of Smurf2 associated with controlling chromatin landscape and genome stability through RNF20.50
188217062008Induction of an osteoarthritis-like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic mice.44
232509562013Effect of SMURF2 targeting on susceptibility to MEK inhibitors in melanoma.42
191222402009Pin1 down-regulates transforming growth factor-beta (TGF-beta) signaling by inducing degradation of Smad proteins.38
235267932013Smurf2-mediated degradation of EZH2 enhances neuron differentiation and improves functional recovery after ischaemic stroke.37
155745872004Smurf2 up-regulation activates telomere-dependent senescence.36
198051452009E3 ubiquitin ligase COP1 regulates the stability and functions of MTA1.35

Citation

Dessen P

SMURF2 (SMAD specific E3 ubiquitin protein ligase 2)

Atlas Genet Cytogenet Oncol Haematol. 2004-02-01

Online version: http://atlasgeneticsoncology.org/gene/42342/smurf2