SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1)

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SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1)

2003-02-01 Affiliation

Identity

HGNC

LOCATION

2p22.1

LOCUSID

ALIAS

GF1,GGF1,GINGF,HGF,NS4,SOS-1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6654
MIM: 182530
HGNC: 11187
Ensembl: ENSG00000115904

Variants:

dbSNP: 6654
ClinVar: 6654
TCGA: ENSG00000115904
COSMIC: SOS1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000115904	ENST00000395038	G5E9C8
ENSG00000115904	ENST00000402219	Q07889
ENSG00000115904	ENST00000451331	C9K0N6

Expression (GTEx)

0

5

10

15

20

25

30

35

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
MAPK signaling pathway	KEGG	ko04010
ErbB signaling pathway	KEGG	ko04012
mTOR signaling pathway	KEGG	ko04150
Dorso-ventral axis formation	KEGG	ko04320
Focal adhesion	KEGG	ko04510
Gap junction	KEGG	ko04540
Jak-STAT signaling pathway	KEGG	ko04630
Natural killer cell mediated cytotoxicity	KEGG	ko04650
T cell receptor signaling pathway	KEGG	ko04660
B cell receptor signaling pathway	KEGG	ko04662
Fc epsilon RI signaling pathway	KEGG	ko04664
Regulation of actin cytoskeleton	KEGG	ko04810
Insulin signaling pathway	KEGG	ko04910
GnRH signaling pathway	KEGG	ko04912
Renal cell carcinoma	KEGG	ko05211
Endometrial cancer	KEGG	ko05213
Glioma	KEGG	ko05214
Prostate cancer	KEGG	ko05215
Chronic myeloid leukemia	KEGG	ko05220
Acute myeloid leukemia	KEGG	ko05221
Non-small cell lung cancer	KEGG	ko05223
MAPK signaling pathway	KEGG	hsa04010
ErbB signaling pathway	KEGG	hsa04012
mTOR signaling pathway	KEGG	hsa04150
Focal adhesion	KEGG	hsa04510
Gap junction	KEGG	hsa04540
Jak-STAT signaling pathway	KEGG	hsa04630
Natural killer cell mediated cytotoxicity	KEGG	hsa04650
T cell receptor signaling pathway	KEGG	hsa04660
B cell receptor signaling pathway	KEGG	hsa04662
Fc epsilon RI signaling pathway	KEGG	hsa04664
Regulation of actin cytoskeleton	KEGG	hsa04810
Insulin signaling pathway	KEGG	hsa04910
GnRH signaling pathway	KEGG	hsa04912
Pathways in cancer	KEGG	hsa05200
Renal cell carcinoma	KEGG	hsa05211
Endometrial cancer	KEGG	hsa05213
Glioma	KEGG	hsa05214
Prostate cancer	KEGG	hsa05215
Chronic myeloid leukemia	KEGG	hsa05220
Acute myeloid leukemia	KEGG	hsa05221
Non-small cell lung cancer	KEGG	hsa05223
Chemokine signaling pathway	KEGG	ko04062
Chemokine signaling pathway	KEGG	hsa04062
Neurotrophin signaling pathway	KEGG	ko04722
Neurotrophin signaling pathway	KEGG	hsa04722
Dorso-ventral axis formation	KEGG	hsa04320
Hepatitis C	KEGG	ko05160
Hepatitis C	KEGG	hsa05160
Alcoholism	KEGG	hsa05034
Alcoholism	KEGG	ko05034
PI3K-Akt signaling pathway	KEGG	hsa04151
PI3K-Akt signaling pathway	KEGG	ko04151
Proteoglycans in cancer	KEGG	hsa05205
Proteoglycans in cancer	KEGG	ko05205
Estrogen signaling pathway	KEGG	hsa04915
Estrogen signaling pathway	KEGG	ko04915
Prolactin signaling pathway	KEGG	hsa04917
Prolactin signaling pathway	KEGG	ko04917
MicroRNAs in cancer	KEGG	hsa05206
MicroRNAs in cancer	KEGG	ko05206
Ras signaling pathway	KEGG	hsa04014
FoxO signaling pathway	KEGG	hsa04068
Choline metabolism in cancer	KEGG	hsa05231
Choline metabolism in cancer	KEGG	ko05231
Disease	REACTOME	R-HSA-1643685
Diseases of signal transduction	REACTOME	R-HSA-5663202
Signaling by EGFR in Cancer	REACTOME	R-HSA-1643713
Signaling by Ligand-Responsive EGFR Variants in Cancer	REACTOME	R-HSA-5637815
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	REACTOME	R-HSA-1236382
Signaling by EGFRvIII in Cancer	REACTOME	R-HSA-5637812
Constitutive Signaling by EGFRvIII	REACTOME	R-HSA-5637810
Signaling by FGFR in disease	REACTOME	R-HSA-1226099
Signaling by FGFR1 in disease	REACTOME	R-HSA-5655302
Signaling by FGFR2 in disease	REACTOME	R-HSA-5655253
Signaling by FGFR3 in disease	REACTOME	R-HSA-5655332
Signaling by FGFR4 in disease	REACTOME	R-HSA-5655291
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Signaling by the B Cell Receptor (BCR)	REACTOME	R-HSA-983705
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	REACTOME	R-HSA-983695
Innate Immune System	REACTOME	R-HSA-168249
DAP12 interactions	REACTOME	R-HSA-2172127
DAP12 signaling	REACTOME	R-HSA-2424491
RAF/MAP kinase cascade	REACTOME	R-HSA-5673001
Fc epsilon receptor (FCERI) signaling	REACTOME	R-HSA-2454202
FCERI mediated MAPK activation	REACTOME	R-HSA-2871796
FCERI mediated Ca+2 mobilization	REACTOME	R-HSA-2871809
Role of LAT2/NTAL/LAB on calcium mobilization	REACTOME	R-HSA-2730905
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Interleukin-2 signaling	REACTOME	R-HSA-451927
Interleukin receptor SHC signaling	REACTOME	R-HSA-912526
Interleukin-3, 5 and GM-CSF signaling	REACTOME	R-HSA-512988
Hemostasis	REACTOME	R-HSA-109582
Platelet activation, signaling and aggregation	REACTOME	R-HSA-76002
Platelet Aggregation (Plug Formation)	REACTOME	R-HSA-76009
Integrin alphaIIb beta3 signaling	REACTOME	R-HSA-354192
GRB2:SOS provides linkage to MAPK signaling for Integrins	REACTOME	R-HSA-354194
Cell surface interactions at the vascular wall	REACTOME	R-HSA-202733
Tie2 Signaling	REACTOME	R-HSA-210993
Signal Transduction	REACTOME	R-HSA-162582
Signaling by EGFR	REACTOME	R-HSA-177929
GRB2 events in EGFR signaling	REACTOME	R-HSA-179812
SHC1 events in EGFR signaling	REACTOME	R-HSA-180336
Signaling by FGFR	REACTOME	R-HSA-190236
Signaling by FGFR1	REACTOME	R-HSA-5654736
Downstream signaling of activated FGFR1	REACTOME	R-HSA-5654687
FRS-mediated FGFR1 signaling	REACTOME	R-HSA-5654693
SHC-mediated cascade:FGFR1	REACTOME	R-HSA-5654688
Signaling by FGFR2	REACTOME	R-HSA-5654738
Downstream signaling of activated FGFR2	REACTOME	R-HSA-5654696
FRS-mediated FGFR2 signaling	REACTOME	R-HSA-5654700
SHC-mediated cascade:FGFR2	REACTOME	R-HSA-5654699
Signaling by FGFR3	REACTOME	R-HSA-5654741
Downstream signaling of activated FGFR3	REACTOME	R-HSA-5654708
FRS-mediated FGFR3 signaling	REACTOME	R-HSA-5654706
SHC-mediated cascade:FGFR3	REACTOME	R-HSA-5654704
Signaling by FGFR4	REACTOME	R-HSA-5654743
Downstream signaling of activated FGFR4	REACTOME	R-HSA-5654716
FRS-mediated FGFR4 signaling	REACTOME	R-HSA-5654712
SHC-mediated cascade:FGFR4	REACTOME	R-HSA-5654719
Signaling by Insulin receptor	REACTOME	R-HSA-74752
Insulin receptor signalling cascade	REACTOME	R-HSA-74751
IRS-mediated signalling	REACTOME	R-HSA-112399
SOS-mediated signalling	REACTOME	R-HSA-112412
Signal attenuation	REACTOME	R-HSA-74749
Signalling by NGF	REACTOME	R-HSA-166520
p75 NTR receptor-mediated signalling	REACTOME	R-HSA-193704
Cell death signalling via NRAGE, NRIF and NADE	REACTOME	R-HSA-204998
NRAGE signals death through JNK	REACTOME	R-HSA-193648
NGF signalling via TRKA from the plasma membrane	REACTOME	R-HSA-187037
Signalling to ERKs	REACTOME	R-HSA-187687
Signalling to RAS	REACTOME	R-HSA-167044
Signalling to p38 via RIT and RIN	REACTOME	R-HSA-187706
Prolonged ERK activation events	REACTOME	R-HSA-169893
Frs2-mediated activation	REACTOME	R-HSA-170968
ARMS-mediated activation	REACTOME	R-HSA-170984
Signaling by PDGF	REACTOME	R-HSA-186797
Downstream signal transduction	REACTOME	R-HSA-186763
Signaling by VEGF	REACTOME	R-HSA-194138
VEGFA-VEGFR2 Pathway	REACTOME	R-HSA-4420097
VEGFR2 mediated cell proliferation	REACTOME	R-HSA-5218921
Signaling by SCF-KIT	REACTOME	R-HSA-1433557
Regulation of KIT signaling	REACTOME	R-HSA-1433559
Signaling by ERBB2	REACTOME	R-HSA-1227986
SHC1 events in ERBB2 signaling	REACTOME	R-HSA-1250196
GRB2 events in ERBB2 signaling	REACTOME	R-HSA-1963640
Signaling by ERBB4	REACTOME	R-HSA-1236394
SHC1 events in ERBB4 signaling	REACTOME	R-HSA-1250347
MAPK family signaling cascades	REACTOME	R-HSA-5683057
MAPK1/MAPK3 signaling	REACTOME	R-HSA-5684996
Signaling by Rho GTPases	REACTOME	R-HSA-194315
Rho GTPase cycle	REACTOME	R-HSA-194840
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (12/13) signalling events	REACTOME	R-HSA-416482
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907
EGFR Transactivation by Gastrin	REACTOME	R-HSA-2179392
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	REACTOME	R-HSA-2404192
IGF1R signaling cascade	REACTOME	R-HSA-2428924
SHC-related events triggered by IGF1R	REACTOME	R-HSA-2428933
IRS-related events triggered by IGF1R	REACTOME	R-HSA-2428928
Signaling by Leptin	REACTOME	R-HSA-2586552
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
NCAM signaling for neurite out-growth	REACTOME	R-HSA-375165
Signaling by Robo receptor	REACTOME	R-HSA-376176
Activation of Rac	REACTOME	R-HSA-428540
Phospholipase D signaling pathway	KEGG	ko04072
Phospholipase D signaling pathway	KEGG	hsa04072
Signaling by FGFR3 point mutants in cancer	REACTOME	R-HSA-8853338
Signaling by FGFR3 fusions in cancer	REACTOME	R-HSA-8853334
EGFR tyrosine kinase inhibitor resistance	KEGG	ko01521
Endocrine resistance	KEGG	ko01522
EGFR tyrosine kinase inhibitor resistance	KEGG	hsa01521
Endocrine resistance	KEGG	hsa01522
RET signaling	REACTOME	R-HSA-8853659
Breast cancer	KEGG	ko05224
Breast cancer	KEGG	hsa05224
Signaling by MET	REACTOME	R-HSA-6806834
MET activates RAS signaling	REACTOME	R-HSA-8851805

Protein levels (Protein atlas)

Not detected

Low

Medium

High

cerebral cortex

cerebellum

hippocampus

caudate

thyroid gland

parathyroid gland

adrenal gland

nasopharynx

bronchus

lung

oral mucosa

salivary gland

esophagus

stomach 1

stomach 2

duodenum

small intestine

colon

rectum

liver

gallbladder

pancreas

kidney

urinary bladder

testis

epididymis

prostate

vagina

ovary

fallopian tube

endometrium 1

endometrium 2

cervix, uterine

placenta

breast

heart muscle

smooth muscle

skeletal muscle

soft tissue 1

soft tissue 2

adipose tissue

skin 1

skin 2

appendix

spleen

lymph node

tonsil

bone marrow

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA30592	MAP3K1	Gene	Pathway	associated
PA34183	RAF1	Gene	Pathway	associated
PA7360	EGFR	Gene	Pathway	associated

References

Pubmed ID	Year	Title	Citations
38622665	2024	DNMT1/miR-152-3p/SOS1 signaling axis promotes self-renewal and tumor growth of cancer stem-like cells derived from non-small cell lung cancer.	0
38622665	2024	DNMT1/miR-152-3p/SOS1 signaling axis promotes self-renewal and tumor growth of cancer stem-like cells derived from non-small cell lung cancer.	0
35475426	2023	Cardiac features of Noonan syndrome in Japanese patients.	2
37042566	2023	Translational relevance of SOS1 targeting for KRAS-mutant colorectal cancer.	2
37972068	2023	SOS1 and KSR1 modulate MEK inhibitor responsiveness to target resistant cell populations based on PI3K and KRAS mutation status.	2
35475426	2023	Cardiac features of Noonan syndrome in Japanese patients.	2
37042566	2023	Translational relevance of SOS1 targeting for KRAS-mutant colorectal cancer.	2
37972068	2023	SOS1 and KSR1 modulate MEK inhibitor responsiveness to target resistant cell populations based on PI3K and KRAS mutation status.	2
35041140	2022	Knockdown of circRNA-Memo1 Reduces Hypoxia/Reoxygenation Injury in Human Brain Endothelial Cells Through miRNA-17-5p/SOS1 Axis.	14
35152853	2022	miR-148b-3p, as a tumor suppressor, targets son of sevenless homolog 1 to regulate the malignant progression in human osteosarcoma.	3
36403479	2022	SOS1 regulates HCC cell epithelial-mesenchymal transition via the PI3K/AKT/mTOR pathway.	3
36446400	2022	Lack of embryonic homozygous or adult heterozygous lymphatic phenotypes for a Sos1 mutation and lack of lymphatic embryonic phenotypes for a homozygous Cx47 mutation in mice.	0
35041140	2022	Knockdown of circRNA-Memo1 Reduces Hypoxia/Reoxygenation Injury in Human Brain Endothelial Cells Through miRNA-17-5p/SOS1 Axis.	14
35152853	2022	miR-148b-3p, as a tumor suppressor, targets son of sevenless homolog 1 to regulate the malignant progression in human osteosarcoma.	3
36403479	2022	SOS1 regulates HCC cell epithelial-mesenchymal transition via the PI3K/AKT/mTOR pathway.	3

Citation

Dessen P

SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42355/js/case-report-explorer/js/lib/jquery-3.5.1.min.js

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