SPON2 (spondin 2)

2003-02-01 Affiliation

Identity

HGNC

SPON2

LOCATION

4p16.3

LOCUSID

10417

ALIAS

DIL-1,DIL1,M-SPONDIN,MINDIN

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10417
MIM: 605918
HGNC: 11253
Ensembl: ENSG00000159674

Variants:

dbSNP: 10417
ClinVar: 10417
TCGA: ENSG00000159674
COSMIC: SPON2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000159674	ENST00000290902	Q9BUD6
ENSG00000159674	ENST00000431380	Q9BUD6
ENSG00000159674	ENST00000502483	D6RBY3
ENSG00000159674	ENST00000503765	D6RB12
ENSG00000159674	ENST00000509233	D6RFY9
ENSG00000159674	ENST00000511672	A0A1Y8ELY7
ENSG00000159674	ENST00000511679	D6RA41
ENSG00000159674	ENST00000514490	D6REX2
ENSG00000159674	ENST00000515004	D6RIH5
ENSG00000159674	ENST00000617421	Q9BUD6

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
O-linked glycosylation	REACTOME	R-HSA-5173105
O-glycosylation of TSR domain-containing proteins	REACTOME	R-HSA-5173214
Disease	REACTOME	R-HSA-1643685
Diseases of glycosylation	REACTOME	R-HSA-3781865
Diseases associated with O-glycosylation of proteins	REACTOME	R-HSA-3906995
Defective B3GALTL causes Peters-plus syndrome (PpS)	REACTOME	R-HSA-5083635

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
19153605	2009	Structure of the F-spondin domain of mindin, an integrin ligand and pattern recognition molecule.	24
21632881	2011	Cardiac-specific mindin overexpression attenuates cardiac hypertrophy via blocking AKT/GSK3β and TGF-β1-Smad signalling.	23
29440144	2018	SPON2 Promotes M1-like Macrophage Recruitment and Inhibits Hepatocellular Carcinoma Metastasis by Distinct Integrin-Rho GTPase-Hippo Pathways.	20
22615945	2012	Spondin-2 (SPON2), a more prostate-cancer-specific diagnostic biomarker.	17
26686083	2016	SPON2, a newly identified target gene of MACC1, drives colorectal cancer metastasis in mice and is prognostic for colorectal cancer patient survival.	16
19903741	2010	Positive regulation of spondin 2 by thyroid hormone is associated with cell migration and invasion.	15
28991232	2018	The extracellular matrix protein mindin attenuates colon cancer progression by blocking angiogenesis via Egr-1-mediated regulation.	13
25945835	2015	Upregulation of spondin-2 predicts poor survival of colorectal carcinoma patients.	12
25751394	2015	Mindin regulates vascular smooth muscle cell phenotype and prevents neointima formation.	11

Citation

Dessen P

SPON2 (spondin 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42378/spon2