SPRY2 (sprouty RTK signaling antagonist 2)

2003-06-01  

Identity

HGNC
LOCATION
13q31.1
LOCUSID
ALIAS
IGAN3,hSPRY2
FUSION GENES

Other Information

Locus ID:

NCBI: 10253
MIM: 602466
HGNC: 11270
Ensembl: ENSG00000136158

Variants:

dbSNP: 10253
ClinVar: 10253
TCGA: ENSG00000136158
COSMIC: SPRY2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136158ENST00000377102O43597
ENSG00000136158ENST00000377104O43597

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
Signal TransductionREACTOMER-HSA-162582
Signaling by EGFRREACTOMER-HSA-177929
EGFR downregulationREACTOMER-HSA-182971
Signaling by FGFRREACTOMER-HSA-190236
Signaling by FGFR1REACTOMER-HSA-5654736
Negative regulation of FGFR1 signalingREACTOMER-HSA-5654726
Spry regulation of FGF signalingREACTOMER-HSA-1295596
Signaling by FGFR2REACTOMER-HSA-5654738
Negative regulation of FGFR2 signalingREACTOMER-HSA-5654727
Signaling by FGFR3REACTOMER-HSA-5654741
Negative regulation of FGFR3 signalingREACTOMER-HSA-5654732
Signaling by FGFR4REACTOMER-HSA-5654743
Negative regulation of FGFR4 signalingREACTOMER-HSA-5654733

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
124020432002Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway.167
122349202002Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling.72
206387792010miR-27a regulates the growth, colony formation and migration of pancreatic cancer cells by targeting Sprouty2.71
163278842005Medical sequencing of candidate genes for nonsyndromic cleft lip and palate.70
236496312013c-MYC-regulated miR-23a/24-2/27a cluster promotes mammary carcinoma cell invasion and hepatic metastasis by targeting Sprouty2.64
164890042006Sprouty 2, an inhibitor of mitogen-activated protein kinase signaling, is down-regulated in hepatocellular carcinoma.62
175103162007Down-regulation of Sprouty2 in non-small cell lung cancer contributes to tumor malignancy via extracellular signal-regulated kinase pathway-dependent and -independent mechanisms.53
212787892011Downregulation of Spry2 by miR-21 triggers malignancy in human gliomas.50
125937962003hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by c-Cbl.49
182149952008Integration of genomic analysis and in vivo transfection to identify sprouty 2 as a candidate tumor suppressor in liver cancer.47

Citation

Dessen P

SPRY2 (sprouty RTK signaling antagonist 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42381/spry2-(sprouty-rtk-signaling-antagonist-2)