ST13 (ST13 Hsp70 interacting protein)

2003-02-01  

Identity

HGNC
LOCATION
22q13.2
LOCUSID
ALIAS
AAG2,FAM10A1,FAM10A4,HIP,HOP,HSPABP,HSPABP1,P48,PRO0786,SNC6
FUSION GENES

Other Information

Locus ID:

NCBI: 6767
MIM: 606796
HGNC: 11343
Ensembl: ENSG00000100380

Variants:

dbSNP: 6767
ClinVar: 6767
TCGA: ENSG00000100380
COSMIC: ST13

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100380ENST00000216218P50502
ENSG00000100380ENST00000216218A0A140VKA6
ENSG00000100380ENST00000411695F6VDH7
ENSG00000100380ENST00000413424H7C3I1
ENSG00000100380ENST00000455824F8WAQ7
ENSG00000100380ENST00000620312Q3KNR6

Expression (GTEx)

0
100
200
300
400
500
600

Pathways

PathwaySourceExternal ID
Cellular responses to stressREACTOMER-HSA-2262752
Cellular response to heat stressREACTOMER-HSA-3371556
Regulation of HSF1-mediated heat shock responseREACTOMER-HSA-3371453

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10832corticosteroidsChemicalClinicalAnnotationassociatedPD25616159
PA443450AsthmaDiseaseClinicalAnnotationassociatedPD25616159

References

Pubmed IDYearTitleCitations
158455432005The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates alpha-synuclein degradation decisions between proteasomal and lysosomal pathways.102
205345032010Hsp 70/Hsp 90 organizing protein as a nitrosylation target in cystic fibrosis therapy.32
175358102007Functional similarity between the chloroplast translocon component, Tic40, and the human co-chaperone, Hsp70-interacting protein (Hip).21
150710922004The heat shock protein 70 cochaperone hip enhances functional maturation of glucocorticoid receptor.19
217283852011G protein-coupled receptor kinase 5 phosphorylation of hip regulates internalization of the chemokine receptor CXCR4.18
217676362011Akt phosphorylation at Thr308 and Ser473 is required for CHIP-mediated ubiquitination of the kinase.14
156377392005Expression of ST13 in colorectal cancer and adjacent normal tissues.10
256161592015ST13 polymorphisms and their effect on exacerbations in steroid-treated asthmatic children and young adults.9
205129192010ASK1-JNK signaling cascade mediates Ad-ST13-induced apoptosis in colorectal HCT116 cells.5
231250812012ST13, a proliferation regulator, inhibits growth and migration of colorectal cancer cell lines.5

Citation

Dessen P

ST13 (ST13 Hsp70 interacting protein)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42416/st13